Gene interactions and pathways from curated databases and text-mining

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POT1 — PRKAR2A

Text-mined interactions from Literome

Grewal et al., J Biol Chem 2000 : This pathway involves the PKA dependent activation of the Ras related small G-protein, Rap1 , and subsequent stimulation of the neuronal Raf isoform, B-Raf
Tsygankova et al., Mol Cell Biol 2001 : Both cAMP and protein kinase A (PKA) contribute to the regulation of Rap1 activity and signaling by TSH ... Interference with PKA activity blocked phosphorylation but not the activation of Rap1 ... The dual regulation of Rap1 by cAMP and PKA extends to downstream effectors
Schmitt et al., Mol Cell 2002 : We demonstrate here that PKA 's activation of Rap1 was mediated by the Rap1 guanine nucleotide exchange factor C3G, the adaptor Crk-L, the scaffold protein Cbl, and the tyrosine kinase Src
Baldassa et al., Brain Res Mol Brain Res 2003 (MAP Kinase Signaling System) : Moreover, protein kinase A (PKA) activity is required for depolarization induced Rap1 activation and full Erk stimulation, but is not involved in that of Ras ... This PKA dependent Rap1 activation does not require Src family kinases, but, in contrast to Ras, is sensitive to genistein, indicating the involvement of a tyrosine kinase dependent mechanism
Tiwari et al., Blood 2004 (Leukemia, Lymphocytic, Chronic, B-Cell) : The EPAC-specific cAMP analog 8CPT-2Me-cAMP ( 8- ( 4-chloro-phenylthio ) -2'-O-methyladenosine-3',5'-cAMP ) activates Rap1 in B-CLL cells, but, unlike rolipram/forskolin or 8-Bromo-cAMP, it does not induce PKA activation, as judged by phosphorylation of the transcription factor cAMP-response element binding protein ( CREB )
Obara et al., J Cell Sci 2004 : In these cells, Rap1 is required for cAMP/PKA signaling to ERKs and also for the sustained activation of ERKs by NGF ... PKA phosphorylation of Src may therefore be required for Rap1 activation in PC12 cells
Ji et al., Mol Cell Biol 2005 (Second Messenger Systems) : In NC cultures, high-level activation of cAMP signaling mediates protein kinase A (PKA) dependent Rap1-B-Raf-ERK1/2 activation, leading to cytoplasmic accumulation of phospho-Smad1, thus terminating bone morphogenetic protein 2 (BMP2) induced sympathoadrenal cell development
Moon et al., J Neurosci Res 2005 : In contrast, the Epac-specific cAMP analog 8- ( 4-chloro-phenylthio ) -2'-O-methyladenosine-3',5'-cyclic monophosphate ( 8CPT-2Me-cAMP ) activates Rap1 in the BV2 cells, but does not induce PKA activation, as judged by CREB phosphorylation
Wang et al., Mol Cell Biol 2006 : Using a small interfering RNA approach, we demonstrate that C3G is required for the activation of ERKs and Rap1 by cAMP/PKA
Li et al., Mol Endocrinol 2007 (Colorectal Neoplasms) : The small GTPase Rap1 can be activated by both PKA and Epac ; however, the role of Rap1 in hormone secretion is unknown ... PKA activation increased NT release and Rap1 activity
Obara et al., J Neurochem 2007 : We show that both Ras and Rap1 can be activated by cAMP or PACAP via protein kinase (PKA) dependent mechanisms
Xie et al., Mol Pharmacol 2007 (MAP Kinase Signaling System...) : Furthermore, PKA dependent Rap1 activation is required for both ERK1/2 activation and androgen independent AR activation in LNCaP cells upon VIP stimulation
Hochbaum et al., J Biol Chem 2008 : Since cAMP mediated activation of the G-protein Rap1 and its phosphorylation by PKA are strictly required for the effects of cAMP on mitogenesis, we hypothesized that the Rap1 activator Epac might represent the PKA independent factor
Yokoyama et al., J Biol Chem 2008 : A specific EP4 agonist, ONO-AE1-329, increased Rap1 activity in the presence of a PKA inhibitor, PKI- ( 14-22 ) -amide, in DA smooth muscle cells
Matsumoto et al., Mol Med Report 2008 : In K1 cells, B-Raf might predominate over Raf-1, and the elevated cAMP is thought to promote MAPK phosphorylation through the PKA mediated activation of Rap1
Subramanian et al., Journal of thrombosis and haemostasis : JTH 2013 (Calcium Signaling) : Phosphorylation of S587 correlated with the inhibitory effect of PKA on Rap1b activation in platelets
Igual et al., Mol Gen Genet 1996 : We have also analyzed the role of the cAMP dependent protein kinase (PKA) in the transcriptional regulation of POT1