Gene interactions and pathways from curated databases and text-mining

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CASP5 — POLDIP2

Text-mined interactions from Literome

Harada et al., Jpn J Pharmacol 1999 : These results suggest that activation of c-Jun by p38 and/or JNK mediates the activation of caspase in the low KCl induced apoptosis in cerebellar granule neurons
Fecteau et al., J Pharmacol Exp Ther 2002 (Cell Transformation, Neoplastic) : Induction of apoptosis of ras transformed cells by FR901228 correlates with suppression of the extracellular signal regulated kinase ( ERK ) signaling pathway through reduction of Raf expression and deactivation of Mek and Erk, inhibition of the phosphoinositide-3 kinase (PI3-K) pathway indexed by suppression of Akt activity, suppression of p38 activity, and activation of caspase-3
Choi et al., J Biol Chem 2004 : Following 6-hydroxydopamine treatment, inhibition of p38 prevented both caspase-8- and -9-mediated apoptotic pathways as well as generation of truncated Bid
Kwon et al., Life Sci 2007 : IL-1 beta release and caspase-1 activity induced by DSS were significantly inhibited by a MAPK kinase 1/2 inhibitor, a p38 MAPK inhibitor, and NAC, however, not by JNK1/2 or a protein kinase C inhibitor
Yoon et al., Mol Cancer Res 2009 (MAP Kinase Signaling System) : In this study, we show that sphingosine induces death receptor independent caspase-8 activation and apoptotic cell death via p38 mitogen activated protein kinase ( MAPK ) activation and that suppression of the MAPK/extracellular signal regulated kinase ( ERK ) kinase/ERK pathway by protein phosphatase 2A (PP2A) is required for p38 MAPK activation
Yadav et al., Free Radic Biol Med 2010 : Benfotiamine prevented LPS induced apoptosis, expression of the Bcl-2 family of proapoptotic proteins, caspase-3 activation , and PARP cleavage and altered mitochondrial membrane potential and release of cytochrome c and apoptosis inducing factor and phosphorylation and subsequent activation of p38-MAPK , stress activated kinases ( SAPK/JNK ), protein kinase C, and cytoplasmic phospholipase A2 in RAW cells
Brama et al., J Endocrinol Invest 2012 (MAP Kinase Signaling System...) : In conclusion, at least 2 pathways appear activated by cadmium in osteoblasts : a direct induction of caspase-8 followed by activation of caspase-3 and an indirect induction by phosphorylation of ERK1/2, p38 , and JNK MAPK triggering activation of caspase-8 and -3