Gene interactions and pathways from curated databases and text-mining

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IGF1 — PML

Text-mined interactions from Literome

Estrov et al., J Clin Oncol 1991 (Leukemia, Myeloid, Acute...) : Under serum-free conditions hGH and IGF-1 induced a significant dose dependent proliferative effect on promyelocytic leukemia ( HL60 ) and Burkitt 's lymphoma ( Daudi ) cell lines
Reineke et al., J Biol Chem 2010 (Leukemia, Promyelocytic, Acute) : Promyelocytic leukemia protein controls cell migration in response to hydrogen peroxide and insulin-like growth factor-1 ... Taken together, our work identifies PML as a common target for H ( 2 ) O ( 2 ) and IGF-1 and supports a novel tumor suppressive role for PML in controlling cell migration through the expression of ITGB1