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MAPK14 — PLAU

Text-mined interactions from Literome

Nguyen et al., J Cell Biol 1999 : Urokinase-type plasminogen activator ( uPA ) activates the mitogen activated protein ( MAP ) kinases , extracellular signal regulated kinase ( ERK ) 1 and 2, in diverse cell types
Benasciutti et al., Blood 2004 (MAP Kinase Signaling System) : In HeLa cells the dominant negative form of JNK interferes with the p42/p44 MAPK activation of the uPA-MP
Nicholl et al., J Vasc Surg 2005 : Activation of the mitogen activated protein kinases ( MAPK ), extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38 MAPK, Akt, MAP kinase/ERK kinase ( MEK1/2 ), MAP kinase kinase (MKK)3/6, and epidermal growth factor receptor (EGFR) in response to uPA was assayed by Western blot analysis for the phosphorylated form of each kinase ... Although uPA induced phosphorylation of both ERK1/2 and p38 MAPK was blocked by Galphai inhibition, inhibition of PI3K and Ras decreased the uPA induced phosphorylation of ERK1/2 but not p38 MAPK
Gandhari et al., Int J Oncol 2006 (Breast Neoplasms) : Our study aimed to determine the role of uPA in both proliferation and mitogen activated protein kinase ( MAPK ) pathway
Estrella et al., Int J Oncol 2007 (MAP Kinase Signaling System...) : Specific inhibitors were utilized to determine if interference with the p38 ( MAPK ), p42/44(MAPK), and PI3K pathways functionally blocked LPA mediated uPA secretion ... Inhibition of p38 ( MAPK ) signaling by SB202190 completely abrogated LPA induced uPA secretion, while inhibition of the p42/44(MAPK) or PI3K pathways with PD98059 or wortmannin and LY294002, respectively, decreased but did not completely block uPA secretion ... These results indicate that the p38 ( MAPK ) signaling pathway is required for optimal LPA dependent uPA secretion from ovarian cancer cells
Fuhrman et al., Atherosclerosis 2007 (Atherosclerosis...) : These latter effects were mediated by uPA induced activation of the mitogen activated protein kinase/extracellular signal regulated kinase ( MEK )
Armstead et al., Brain Res 2008 (Hypercapnia...) : Exogenous uPA administered at 4 h post H/I further stimulated ERK MAPK phosphorylation, which was blocked by RAP
Amos et al., J Neuropathol Exp Neurol 2010 (Glioblastoma...) : Small-molecule inhibitors of mitogen activated protein kinase , tyrosine kinase, and small interfering RNA targeting c-Src blocked uPA upregulation ... In summary, these results suggest that c-Src, mitogen activated protein kinase , and a composite activator protein 1 on the uPA promoter are responsible for EGF induced uPA expression and GBM invasion
Tang et al., J Biol Chem 1998 : The uPA induced activation of MAPK was completely inhibited by genistein, but not by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3, 4-d ] pyrimidine, a specific inhibitor of Src family kinases