◀ Back to IGF1

IGF1 — PLAU

Text-mined interactions from Literome

Sieuwerts et al., Mol Cell Endocrinol 1999 : These data suggest that in human breast fibroblasts IGF-1 controls the expression of uPA and that, possibly due to an altered sensitivity to uPA, tumor associated fibroblasts have escaped this local control mechanism
Hilal et al., Arthritis Rheum 1999 (Osteoarthritis) : Abnormal regulation of urokinase plasminogen activator by insulin-like growth factor 1 in human osteoarthritic subchondral osteoblasts
Dunn et al., Cancer Res 2001 (Breast Neoplasms...) : In this study, we investigated the signal transduction pathway through which IGF-I regulates uPA ... Induction of uPA protein by IGF-I was partially inhibited by LY294002 ( 60 % inhibition ) or PD98059 ( 30 % inhibition ) but not by rapamycin ... Next, using a minimal uPA-luciferase promoter construct containing the binding sites for the AP-1 and Ets transcription factors, we observed that IGF-I stimulated the uPA promoter via these sites ... Furthermore, both Ly294002 and PD98059 were necessary to block IGF-I stimulated uPA-Luc activity ... In summary, we conclude that IGF-I requires both phosphatidylinositol 3-kinase and mitogen activated protein kinase kinase dependent pathways to optimally induce uPA expression
Gallicchio et al., J Cell Physiol 2003 (Rhabdomyosarcoma) : Urokinase type plasminogen activator receptor is involved in insulin-like growth factor induced migration of rhabdomyosarcoma cells in vitro
Tanaka et al., Int J Cancer 2004 (MAP Kinase Signaling System...) : IGF-I induced IGFBP-4 proteolysis by PAPP-A may enhance cell growth and invasion through IGF-I dependent Akt and ERK1/2 activation and subsequently upregulation of uPA
MacEwen et al., J Cell Biochem 2004 (Bone Neoplasms...) : Cell lines were evaluated for : IGF-1R expression ; expression of IGF binding proteins ( IGFBPs ) ; effect of IGF-1 on tumor cell growth, invasion, expression of urokinase plasminogen activator (uPA), and soluble uPA receptor ( suPAR ), and ; ectopic and orthotopic tumorigenicity of the canine OS cells in athymic mice
Papatsoris et al., Trends Mol Med 2005 (Prostatic Neoplasms) : Moreover, it has been suggested that IGF-1 induces ligand independent activation of the androgen receptor and enhances the expression of matrix metalloproteinase-2 and urokinase plasminogen activator
Bauer et al., Ann Surg 2005 (Colorectal Neoplasms...) : IGF-I and HGF cooperate to induce migration and invasion of CRC cells, and c-Met and uPA/uPAR are required for IGF-I mediated migration and invasion
Matsuzaki et al., Oncol Rep 2005 (Neoplasm Invasiveness...) : Here, we show : 1 ) there was lower proliferation in the AS syndecan-1 cells compared to controls ( parental HRA cells and S syndecan-1 cells ) when cells were incubated with HB-GFs ( HB-EGF, HGF, or FGF2 ) ; 2 ) transfection of HRA cells with a syndecan-1 AS ODN enhanced the increase in HB-GF dependent invasiveness ; 3 ) in contrast, IGF-I stimulated cell proliferation and invasion, irrespective of whether cells were transfected with the AS syndecan-1 gene ; 4 ) IGF-I stimulated ERK1/2 activation and uPA expression in both the control and AS cells, whereas the net effect of the reduction of syndecan-1 is to shift the HB-GF dose-response curve to the right ; 5 ) the AS cells reduced activation and up-regulation of ERK1/2 phosphorylation and uPA expression, respectively, in response to HB-GFs ; and 6 ) in comparison with early stage ovarian cancer tissues, there was a 3-fold decrease in syndecan-1 mRNA levels in advanced stage tissues
Bauer et al., Cancer Res 2005 (Liver Neoplasms, Experimental...) : In addition, IGF-I and HGF induced uPA and uPAR expression in L3.6pl cells ... In addition, IGF-I and HGF induced uPA and uPAR expression in L3.6pl cells ... We investigated the hypotheses that ( a ) insulin-like growth factor-I (IGF-I)- and hepatocyte growth factor (HGF) mediated migration and invasion of human pancreatic carcinoma cells require uPA and uPAR function and ( b ) inhibition of uPAR inhibits tumor growth, retroperitoneal invasion, and hepatic metastasis of human pancreatic carcinomas in mice
Cao et al., Matrix Biol 2006 : Insulin-like growth factor-I stimulated SERPINE2 secretion and uPA activity, and decreased secreted tPA activity and gene expression
Guerra et al., Int J Cancer 1996 (Adenocarcinoma...) : In addition, we found that IGF-I enhanced secreted uPA activity in both M3 and MM3 cells while IGF-II only stimulated uPA secretion in MM3 cells
Politis et al., J Dairy Sci 1996 : Insulin and IGF-I increased synthesis of urokinase plasminogen activator and enhanced proliferation of cultured bovine mammary epithelial cells