Son et al., Biochem Biophys Res Commun 2002
(MAP Kinase Signaling System) :
Soluble NCAM transiently inhibited tPA mRNA expression levels in a MAPK dependent manner, while stimulation of MAPK alone induced tPA reduction in cells ... In turn, MAPK activation may cause tPA degradation or a decrease in expression to promote synaptic plasticity
Yang et al., Endocrine 2008
:
We have analyzed a possible role of mitogen activated protein kinase ( MAPK ) and activator protein-1 (AP-1) in the regulation of FSH induced tissue type plasminogen activator (tPA) production in granulosa cells (GCs) prepared from DES treated immature rats ; Treatment of the cells in the presence of FSH with MAPK inhibitors, such as UO126 or SB203580, significantly decreased the FSH induced tPA production, suggesting that multiple signaling pathways may be involved in FSH regulated tPA expression
Armstead et al., Pediatr Crit Care Med 2011
(Toxoplasmosis, Cerebral) :
Red blood cells-tissue plasminogen activator blocked c-Jun-N-terminal kinase but potentiated p38 mitogen activated protein kinase upregulation after photothrombotic injury