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IGF2 — PLAG1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
IGF2
→
PLAG1
(increases)
Evidence: Table 2. Identification of genes consistently and significantly induced by PLAG1. Genes induced by at least 2.5-fold in each of 2 sets of Plag1 overexpressing clones compared to 2 sets of control cells.
Text-mined interactions from Literome
Zatkova et al., Genes Chromosomes Cancer 2004
(Hepatoblastoma...) :
Thus, our results provide evidence that
PLAG1 overexpression may be
responsible for the frequently observed up-regulation of
IGF2 in hepatoblastoma and therefore may be implicated in the molecular pathogenesis of this childhood neoplasia
Zheng et al., J Biol Chem 2005
:
Further study showed that sumoylation inhibits
PLAG1 induced
IGF-II expression in reporter assays