Gene interactions and pathways from curated databases and text-mining

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PLA2G4A — PLD3

Text-mined interactions from Literome

Burke et al., Biochem Biophys Res Commun 1999 : In the present research, a role for phospholipase D ( PLD ) in the regulation of cPLA2 was shown based on a number of observations ... Further evidence for the involvement of PLD in the regulation of cPLA2 came from the observation that the stimulated production of diacylglycerol ( for which phosphatidic acid is a major source ) was greatly diminished in undifferentiated cells as compared to differentiated cells
Kitatani et al., Biol Pharm Bull 2000 (Leukemia, Basophilic, Acute) : These results suggest that PA formed by the catalytic action of PLD is used as a substrate for cPLA2, thus PLD regulates cPLA2 activation in antigen stimulated RBL-2H3 cells
Parmentier et al., J Biol Chem 2001 : These data suggest that HETEs are the mediators of cPLA(2) dependent PLD activation by NE in VSMC
Li et al., J Pharmacol Exp Ther 2005 : Furthermore, ETYA, cPLA(2) antisense, and cPLA(2) siRNA attenuated Ang II-elicited PLD activation
Flamand et al., Br J Pharmacol 2006 : No alteration of phospholipase D ( PLD ) activity in fMLP activated PMN was observed with up to 10 microM pyrrophenone, suggesting that the cPLA2alpha inhibitor does not directly inhibit PLD