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MAPK6 — PLA2G4A

Text-mined interactions from Literome

Gijón et al., J Leukoc Biol 1999 : In macrophages, zymosan induces a transient increase in intracellular calcium and activation of MAPK , which together fully activate cPLA2 and synergistically promote arachidonic acid release
Geijsen et al., FEBS Lett 2000 (MAP Kinase Signaling System) : Cytokine mediated cPLA(2) phosphorylation is regulated by multiple MAPK family members ... GM-CSF induced cPLA(2) phosphorylation was not affected by pharmacological inhibition of p38 MAPK , phosphatidylinositol 3-kinase or Src
Fonteh et al., J Immunol 2000 : Additionally, an inhibitor of p44/p42 mitogen activated protein kinase ( PD98059 ) significantly inhibited sPLA2 induced cPLA2 activation and AA release
Wen et al., J Cell Biochem 2000 : On the other hand, rottlerin ( the selective PKCdelta inhibitor ), SB 203580 ( the selective p38 MAPK inhibitor ), and wortmannin ( the PI 3-kinase inhibitor ) can affect neither cPLA(2) nor ERK phosphorylation
Sano et al., J Immunol 2001 : Preincubation of eosinophils with U0126 or PD98059, two structurally unrelated MAPK kinase inhibitors, or arachidonic trifluoromethyl ketone, a cPLA(2) inhibitor , blocked eosinophil adhesion to FN
Siegel et al., J Biol Chem 2001 (Calcium Signaling...) : Agonist induced activation of cPLA2 involves mitogen activated protein kinase ( MAPK ) activation
Misra et al., Arch Biochem Biophys 2001 (Calcium Signaling...) : We conclude that alpha2M* induced cPLA2 synthesis is controlled by [ Ca2+ ] i levels, tyrosine kinase activity, the p21ras dependent MAPK and PI 3-kinase downstream signaling pathways, and regulation of NFkappaB
Zhu et al., J Immunol 2001 (MAP Kinase Signaling System) : We also find that cPLA(2) activation caused by fMLP occurs subsequent to and is dependent upon ERK1/2 and p38 MAPK activation
Kalyankrishna et al., J Pharmacol Exp Ther 2003 : NE-induced p38 MAPK activation was found to be mediated through the stimulation of alpha-1 and alpha-2 adrenergic receptors, was dependent on extracellular Ca ( 2+ ), and was attenuated by an inhibitor of cPLA(2) ( pyrrolidine-1 ) ... Moreover, the cPLA(2) product, AA, activated p38 MAPK in VSMC
Chakraborti et al., Cell Signal 2003 (MAP Kinase Signaling System) : Recently, a negative feed back loop for cPLA(2) activation by MAPK has been proposed
Li et al., J Pharmacol Exp Ther 2005 : These data indicate that Ang II-stimulated Akt activity is mediated by cPLA(2) dependent, p38 MAPK regulated PLD(2) activation and EGFR transactivation
Leoncini et al., Journal of thrombosis and haemostasis : JTH 2006 (Calcium Signaling) : The cPLA2 phosphorylation and activation were both impaired by the inhibition of p38 MAPK through SB203580
Engelbrecht et al., Prostaglandins Leukot Essent Fatty Acids 2007 (MAP Kinase Signaling System...) : Therefore, the aim of this study was to investigate the role of cPLA(2) in MAPK phosphorylation and apoptosis in simulated ischaemia/reperfusion ( SI/R ) -induced injury in neonatal cardiomyocytes
Kang et al., Int Arch Allergy Immunol 2008 (Anaphylaxis) : TNF-alpha-induces cPLA(2) activation through the pathway involving p38 MAPK and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis
Hoffmann et al., Biochim Biophys Acta 2010 : Hyperforin induced phosphorylation of cPLA(2) at Ser505 and activated p38 mitogen activated protein kinase ( MAPK ), and inhibition of p38 MAPK by SB203580 prevented cPLA(2) phosphorylation
Wang et al., Invest Ophthalmol Vis Sci 2011 : cPLA(2)a is regulated by calcium mobilization and mitogen activated protein kinases ( MAPK ) activation
Slomiany et al., Inflammopharmacology 2013 : Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on MAPK/ERK mediated activation of IKK-ß and cPLA2 : modulatory effect of ghrelin
Börsch-Haubold et al., J Biol Chem 1995 : Collagen, thrombin, and PDBu induced phosphorylation of platelet cPLA2 as well as activation of mitogen activated protein kinase ( MAPK ; p42mapk and p44mapk ) ... Although MAPK may underlie phosphorylation of cPLA2 in PDBu activated human platelets, our results provide evidence for PKC- and MAPK independent phosphorylation of cPLA2 in platelets stimulated by the physiological activators collagen and thrombin
Sa et al., J Biol Chem 1995 : Since arachidonate release is required for basic FGF stimulated motility of EC, our results show that p42 mitogen activated protein kinase activation of cPLA2 may be a regulatory event in stimulation of cellular release of this important eicosanoid precursor during cellular responses to basic FGF
Sakanaka et al., Biochem Biophys Res Commun 1994 : SSTR4 activated mitogen activated protein ( MAP ) kinase and induced the phosphorylation of 85kDa cytosolic phospholipase A2 (cPLA2) , in a PTX-sensitive manner
Hernández et al., Biochem J 1997 (Astrocytoma) : Evidence that the cytosolic phospholipase A2 (cPLA2) takes part in thrombin induced arachidonate release was provided by the finding that thrombin induced retardation of the mobility of cPLA2 in SDS/polyacrylamide gels, which is a feature of the activation of cPLA2 by mitogen activated protein ( MAP ) kinases
Pyne et al., Biochem J 1997 : This occurs via a pathway that involves : ( 1 ) the protein kinase C ( PKC ) -dependent activation of mitogen activated protein kinase ( MAPK); (2 ) the MAPK dependent phosphorylation and activation of cytosolic phospholipase A2 (cPLA2) and ( 3 ) the utilization of cPLA2 derived arachidonate by the cyclo-oxygenase pathway to produce prostaglandin E2 ( PGE2 ) ... Acute treatment of ASM cells with PMA ( a direct activator of PKC ) also stimulated the MAPK dependent phosphorylation of cPLA2
Hayama et al., J Biochem 1997 : These data suggest that glucose induced cPLA2 activation through MAPK activation is responsible for the enhancement of PGE2 production in mesangial cells
Nakahata et al., Nihon Yakurigaku Zasshi 1997 : Then, MAPK is activated by a PKC pathway, then cPLA2 is activated by MAPK
Husain et al., Biochim Biophys Acta 1998 : The data presented are consistent with a role for PKCalpha, but not for p42/p44 mitogen activated protein kinase ( MAPK ), in cPLA2 activation and AA release in ET-1 stimulated CISM cells since : ( i ) the PKC inhibitor, RO 31-8220, inhibited ET-1 induced AA release, cPLA2 phosphorylation and cPLA2 activity, but had no inhibitory effect on p42/p44 MAPK activation, ( ii ) genistein, a tyrosine kinase inhibitor, inhibited ET-1 stimulated MAPK activity but had no inhibitory effect on AA release in the ET-1 stimulated cells
Cybulsky et al., Kidney Int 1998 (Glomerulonephritis, Membranous) : The role of p42 MAPK in cPLA2 activation becomes redundant in the presence of relatively potent PKC activation
Pyne et al., Cell Signal 1998 : cPLA2 is regulated by mitogen activated protein kinase ( MAPK ) in a number of cell types