Gene interactions and pathways from curated databases and text-mining

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IL22 — PLA2G1B

Text-mined interactions from Literome

Vadas et al., Infect Immun 1992 (Malaria) : Since both interleukin 1 and tumor necrosis factor induce expression of the proinflammatory enzyme phospholipase A2 (PLA2) , we examined serum PLA2 levels in 14 adults with malaria
Mühl et al., FEBS Lett 1992 : In contrast, interleukin-6 did not increase PLA2 mRNA levels of PLA2 activity
Gilman et al., Agents Actions 1987 : Phospholipase A2 activation by interleukin 1 : release and metabolism of arachidonic acid by IL 1-stimulated rabbit chondrocytes
Godfrey et al., Prostaglandins 1988 (Osteoarthritis) : Recombinant interleukin-1 induced an approximate 3-fold increase in [ 3H ] -AA release, a 7-fold increase in PGE2 production and a 2-fold increase in PLA2 activity in human synovial fibroblasts ... These data show that tumor necrosis factor and interleukin-1 can both activate synovial cell PLA2 and induce generation of PGE2, but act in an additive rather than a synergistic fashion
Keuter et al., J Infect Dis 1995 (Typhoid Fever) : The 14-kDa group II extracellular phospholipase A2 (PLA2) is induced by interleukin-1 and tumor necrosis factor and may mediate some of the effects of these cytokines
Vervoordeldonk et al., Biochim Biophys Acta 1994 : Under conditions where 14 kDa group II PLA2 activity and protein levels were dramatically affected by interleukin-1 and dexamethasone, the level of annexin I in the cells remained constant