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AKT1 — PIKFYVE
Text-mined interactions from Literome
Berwick et al., J Cell Sci 2004
:
Finally, we demonstrate that overexpression of a PIKfyve [ S318A ] mutant in 3T3-L1 adipocytes enhances insulin stimulated IRAP/GLUT4 vesicle translocation to the plasma membrane suggesting a role for
PKB dependent phosphorylation of
PIKfyve in insulin regulated IRAP/GLUT4 trafficking
Ikonomov et al., Exp Cell Res 2007
:
Loss of
PIKfyve-ArPIKfyve reduced insulin stimulated
Akt phosphorylation and the cell surface accumulation of GLUT4 or IRAP, but not GLUT1 containing vesicles without affecting overall expression of these proteins
Hill et al., Biochem Biophys Res Commun 2010
:
We have previously demonstrated that
PIKfyve is phosphorylated in response to insulin in a PI3-kinase and
protein kinase B (PKB) dependent manner
Munoz et al., J Membr Biol 2013
(Andersen Syndrome) :
The ubiquitously expressed
protein kinase B ( PKB/Akt )
activates the phosphatidylinositol-3-phosphate-5-kinase
PIKfyve , which in turn regulates a variety of carriers and channels
Pakladok et al., Cell Physiol Biochem 2013
:
SGK's and
PKB/Akt's activate phosphatidylinositol-3-phosphate-5-kinase
PIKfyve , which in turn up-regulates several carriers and channels ... SGK's and
PKB/Akt's activate phosphatidylinositol-3-phosphate-5-kinase
PIKfyve , which in turn up-regulates several carriers and channels ... Conclusion : hERG is up-regulated by
PIKfyve , which is in turn
activated by
PKB/Akt ... Conclusion : hERG is up-regulated by
PIKfyve , which is in turn
activated by
PKB/Akt
Er et al., Science signaling 2013
:
Upon EGF stimulation,
AKT phosphorylated and
activated the kinase
PIKfyve [ FYVE containing phosphatidylinositol 3-phosphate 5-kinase ], which promoted vesicle trafficking to lysosomes ... Similar regulation occurred with platelet derived growth factor receptor ( PDGFR ), suggesting that
AKT phosphorylation and
activation of
PIKfyve is likely to be a common feedback mechanism for terminating RTK signaling and reducing receptor abundance