Miyakawa et al., J Biol Chem 2001
:
In primary murine MKs, TPO also induced phosphorylation of SHP2, its association with p85 and enhanced PI3K activity, but in contrast to the results in cell lines, neither Gab2 nor IRS2 are phosphorylated in MKs
Kojima et al., Exp Hematol 2001
(MAP Kinase Signaling System) :
TPO induces the association of tyrosine phosphorylated Gab1 with p85-PI3K Soda et al., Cell Signal 2008
:
Previously we and others have shown that TPO activates PI3K and Akt and that this pathway is important for megakaryocyte growth