Gene interactions and pathways from curated databases and text-mining

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CHUK — PIK3CA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Chen et al., J Biol Chem 2007 : In conclusion, MEK1, TAK1, NF-kappa inducing kinase, and PI3K are required for iron induced IKK activation in hepatic macrophages and TAK1, PI3K, and p21ras physically interact in caveolae to initiate signal transduction
Comb et al., Mol Cell 2012 (Starvation) : Finally, leucine deprivation is shown to be necessary and sufficient for starvation induced, IKK mediated p85 phosphorylation and PI3K feedback inhibition