Gene interactions and pathways from curated databases and text-mining

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CASP7 — PIDD

Text-mined interactions from Literome

Tinel et al., Science 2004 : Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli
Ren et al., Proc Natl Acad Sci U S A 2005 (Embryo Loss) : This apoptosis is associated with up-regulation and nuclear localization of the tumor suppressor p53 and activation of mitochondrial apoptosis, which includes up-regulation of Bax, Bak, and Pidd , translocation of Bax and caspase-2 onto mitochondria, release of cytochrome c and apoptosis inducing factor, and activation of caspase-9 and caspase-3
Manzl et al., J Cell Biol 2009 : Because loss of either PIDD or its adapter molecule RAIDD did not affect subcellular localization, nuclear translocation, or caspase-2 activation in high molecular weight complexes, we suggest that at least one alternative PIDDosome independent mechanism of caspase-2 activation exists in mammals in response to DNA damage