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CASP5 — PI3

Text-mined interactions from Literome

Leverrier et al., Cell Death Differ 1999 : Moreover, PI3-kinase activity is also necessary for inhibition of apoptosis and caspase regulation by IGF-1 but not IL-3
Zhang et al., Cell Death Differ 2001 (MAP Kinase Signaling System) : PI3-kinase/Akt signaling attenuated caspase-8 activity, whereas MAP kinase signaling impaired caspase-9 activity
Goyal et al., Am J Respir Cell Mol Biol 2002 : These results suggest that monocyte survival factors may suppress DNA fragmentation, caspase-9 , and caspase-3 activation in a PI 3-kinase dependent manner, perhaps through the activation of Akt
Bild et al., Oncogene 2002 : MEKK1 induced apoptosis is amplified by blocking PI-3 kinase activation and overexpression of AKT blocked both MEKK1 induced apoptosis and caspase activation
Pavalko et al., J Cell Physiol 2003 : FSS activated PI3-kinase signaling, induced phosphorylation of Akt, and inhibited TNF-alpha induced activation of caspase-3 ... Inhibition of PI3-kinase , using LY294002, blocked the ability of FSS to rescue osteoblasts from TNF-alpha induced apoptosis and blocked FSS induced inhibition of caspase-3 activation in osteoblasts treated with TNF-alpha
Burgess et al., J Neuroimmunol 2003 : IGF-I fails to reduce caspase-3 activity and cell death in the presence of the PI 3-kinase inhibitors, wortmannin and LY294002, whereas these blockers do not affect the ability of IL-3 to maintain cell survival
Marzioni et al., Am J Physiol Gastrointest Liver Physiol 2003 : The protective effect of taurocholate was associated with maintenance of ABAT activity, downregulation of caspase 8, 9, and 3, and activation of PI3-kinase
Kaushal et al., American journal of physiology. Renal physiology 2004 : These downstream effects of PI 3-kinase inhibition promoted the oxidant induced activation of caspase-3 and -9, but not caspase-8 and -1
Plate et al., Leukemia & lymphoma 2004 (Leukemia, Lymphocytic, Chronic, B-Cell) : PI3-kinase regulates survival of chronic lymphocytic leukemia B-cells by preventing caspase 8 activation
Xifro et al., Eur J Neurosci 2005 : By contrast, K25 mediated neuroprotection was BDNF independent and was mediated by a mitogen activated protein kinase- and PI3-kinase dependent inhibition of caspase-3
Hodkinson et al., Cell Death Differ 2006 (Carcinoma, Small Cell...) : We demonstrate that extracellular matrix ( ECM ) activates phosphatidyl inositol 3-kinase ( PI3-kinase ) signaling in SCLC cells and prevents etoposide induced caspase-3 activation and subsequent apoptosis in a beta1 integrin/PI3-kinase dependent manner
Granado-Serrano et al., J Nutr 2006 (Carcinoma, Hepatocellular...) : Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line ( HepG2 )
Gao et al., J Appl Physiol 2008 : Regulation of caspase-3 activity by insulin in skeletal muscle cells involves both PI3-kinase and MEK-1/2 ... Addition of insulin to proteolytically active cells attenuated both responses within 4 h. Individually, inhibitors of either phosphatidylinositide 3-kinase (PI3K) or MEK1/2 partially blocked the insulin induced reduction in caspase-3 activity ; in combination, the inhibitors completely prevented insulin from attenuating caspase-3 activity
Seol et al., Biochem Biophys Res Commun 2008 : My data indicate that in addition to blocking Bad and caspase-9 through Akt, PI-3K also inhibits caspase-3 through up-regulating IAPs, thereby attenuates apoptosis
Xiang et al., Cell Biochem Funct 2011 : The inhibitory effect of ghrelin on caspase-3 activity was attenuated by inhibitors of ERK1/2 ( PD98059 ), PI3K/Akt ( LY294002 ) and growth hormone secretagogue receptor ( GHSR ) -1a ( D-Lys ( 3 ) -growth hormone releasing peptide-6 )
Srivastava et al., Carcinogenesis 2012 : Phosphoinositide 3-kinase (PI3K) or autophagy inhibitors increased neem induced caspase-3 activation and inhibition of caspases enhanced neem induced autophagy
Chen et al., Oncogene 1998 : Activation of PI 3-kinase did not lead to a suppression of Smad hetero-oligomerization or nuclear translocation but blocked TGF-beta induced caspase-3-like activity