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AKT1 — PHLPP1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Li et al., Mol Cell Biol 2009
:
Taken together, our findings demonstrate a key role for beta-TrCP in controlling the level of
PHLPP1 , and activation of
Akt negatively
regulates this degradation process
Kanan et al., J Neurochem 2010
:
In this study, we characterized these two phosphatases in the retina and examined the
role of IR, PI3K, and
Akt signaling on the activity of
PHLPP and PHLPPL
Miyamoto et al., Circ Res 2010
:
PHLPP-1 negatively
regulates Akt activity and survival in the heart
Liu et al., J Biol Chem 2011
(Colonic Neoplasms) :
Thus, our studies identify a compensatory feedback regulation in which the activation of
Akt is
inhibited by up-regulation of
PHLPP through mTOR, and this mTOR dependent expression of PHLPP subsequently determines the rapamycin sensitivity of cancer cells
Mulholland et al., Cancer Cell 2011
(Prostatic Neoplasms) :
Conditional deletion of Ar in the epithelium promotes the proliferation of Pten null cancer cells, at least in part, by downregulating the androgen-responsive gene Fkbp5 and preventing
PHLPP mediated
AKT inhibition
Beezhold et al., Toxicological sciences : an official journal of the Society of Toxicology 2011
(Arsenic Poisoning...) :
miR-190 mediated downregulation of
PHLPP contributes to arsenic induced
Akt activation and carcinogenesis
Nitsche et al., Gastroenterology 2012
(Carcinoma, Pancreatic Ductal...) :
We measured the
effects of
PHLPP overexpression or knockdown with small interfering RNAs on
Akt activation and cell death ... PHLPP overexpression inactivated Akt, whereas
PHLPP knockdown
increased phosphorylation of
Akt in PaCa cells
Gao et al., Mol Biol Rep 2013
(Stomach Neoplasms) :
SGT1
regulates Akt signaling by promoting beta-TrCP dependent
PHLPP1 degradation in gastric cancer cells