Gene interactions and pathways from curated databases and text-mining

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AKT1 — PHLPP1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Li et al., Mol Cell Biol 2009 : Taken together, our findings demonstrate a key role for beta-TrCP in controlling the level of PHLPP1 , and activation of Akt negatively regulates this degradation process
Kanan et al., J Neurochem 2010 : In this study, we characterized these two phosphatases in the retina and examined the role of IR, PI3K, and Akt signaling on the activity of PHLPP and PHLPPL
Miyamoto et al., Circ Res 2010 : PHLPP-1 negatively regulates Akt activity and survival in the heart
Liu et al., J Biol Chem 2011 (Colonic Neoplasms) : Thus, our studies identify a compensatory feedback regulation in which the activation of Akt is inhibited by up-regulation of PHLPP through mTOR, and this mTOR dependent expression of PHLPP subsequently determines the rapamycin sensitivity of cancer cells
Mulholland et al., Cancer Cell 2011 (Prostatic Neoplasms) : Conditional deletion of Ar in the epithelium promotes the proliferation of Pten null cancer cells, at least in part, by downregulating the androgen-responsive gene Fkbp5 and preventing PHLPP mediated AKT inhibition
Beezhold et al., Toxicological sciences : an official journal of the Society of Toxicology 2011 (Arsenic Poisoning...) : miR-190 mediated downregulation of PHLPP contributes to arsenic induced Akt activation and carcinogenesis
Nitsche et al., Gastroenterology 2012 (Carcinoma, Pancreatic Ductal...) : We measured the effects of PHLPP overexpression or knockdown with small interfering RNAs on Akt activation and cell death ... PHLPP overexpression inactivated Akt, whereas PHLPP knockdown increased phosphorylation of Akt in PaCa cells
Gao et al., Mol Biol Rep 2013 (Stomach Neoplasms) : SGT1 regulates Akt signaling by promoting beta-TrCP dependent PHLPP1 degradation in gastric cancer cells