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IGF1 — PHKA2
Text-mined interactions from Literome
Sekimoto et al., Mol Endocrinol 2005
:
IGF-I increased tyrosine phosphorylation of the focal adhesion kinase ( FAK ) Pyk2 ( calcium dependent proline-rich tyrosine kinase-2 ) to a much greater extent than FAK, and
increased association of Src with
Pyk2 but not FAK ... The intracellular calcium chelator BAPTA prevented IGF-I phosphorylation of Pyk2, Src, and MAPK, suggesting that
IGF-I activation of
Pyk2 is calcium dependent
Genua et al., PloS one 2012
(Carcinoma...) :
On the contrary,
Pyk2 , which was strongly
activated by
IGF-I , was critical for IGF-IR dependent motility and invasion and regulated IGF-I dependent activation of the Akt and MAPK pathways