Gene interactions and pathways from curated databases and text-mining

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IGF1 — PHKA2

Text-mined interactions from Literome

Sekimoto et al., Mol Endocrinol 2005 : IGF-I increased tyrosine phosphorylation of the focal adhesion kinase ( FAK ) Pyk2 ( calcium dependent proline-rich tyrosine kinase-2 ) to a much greater extent than FAK, and increased association of Src with Pyk2 but not FAK ... The intracellular calcium chelator BAPTA prevented IGF-I phosphorylation of Pyk2, Src, and MAPK, suggesting that IGF-I activation of Pyk2 is calcium dependent
Genua et al., PloS one 2012 (Carcinoma...) : On the contrary, Pyk2 , which was strongly activated by IGF-I , was critical for IGF-IR dependent motility and invasion and regulated IGF-I dependent activation of the Akt and MAPK pathways