Gene interactions and pathways from curated databases and text-mining

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MAPK3 — PGR

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Faivre et al., Mol Cell Biol 2007 (Breast Neoplasms) : Progesterone receptor (PR) ligand binding induces rapid and transient ( 5- to 10-min ) activation of cytosolic c-Src-Ras-Erk1/2 mitogen activated protein kinase ( MAPK ) signaling that is independent of PR functioning as transcription factors
Boonyaratanakornkit et al., Mol Endocrinol 2007 (MAP Kinase Signaling System) : Human progesterone receptor (PR) contains a motif that interacts with the SH3 domain of Src and mediates rapid activation of Src and downstream MAPK ( Erk-1/-2 ) without relying on the transcriptional activity of the receptor
Boonyaratanakornkit et al., Steroids 2008 : Human progesterone receptor (PR) contains a polyproline motif in the amino-terminal domain that interacts with the SH3 domain of Src and mediates rapid activation of c-Src and downstream MAPK ( Erk-1/-2 ) independent of the transcriptional activity of PR. Forcedly target PR to different locations in the cell by use of mutations or tags for different cell compartments showed that progestin activation of Src/MAPK is mediated by PR outside the nucleus
Mendoza et al., J Endocrinol 2011 : The reduction in the p38 MAPK activity caused a significant increase in the expressions of estrogen receptor-a ( ERa ) and the progesterone receptor , but eliminated the expression of ERß