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PGP — PRKAR2A

Text-mined interactions from Literome

Parissenti et al., Int J Cancer 1999 (Breast Neoplasms) : In contrast with findings in Chinese hamster ovary and Y1 adrenal cells, P-gp levels and cellular sensitivity to drugs which are P-gp substrates were unchanged in the PKA inhibited transformants, suggesting that P-gp expression and function are not under PKA dependent control in MCF-7 ( ADR ) cells
Wartenberg et al., Int J Cancer 2000 (Prostatic Neoplasms) : Down-regulation of Pgp by H ( 2 ) O ( 2 ) was abolished when either forskolin, 8-Br-cAMP or IBMX, which raise intracellular cAMP levels, was co-administered, indicating that Pgp expression is regulated by protein kinase A (PKA) ... Furthermore, Pgp was down-regulated by the PKA inhibitors Rp-cAMPs and H89