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MAPK3 — PGF

Text-mined interactions from Literome

Desai et al., Biol Reprod 1999 : In contrast, PlGF induced significant ERK-1 and -2 activity in human umbilical vein endothelial cells but did not induce JNK or p38 activity
Chen et al., Endocrinology 2001 : More recently, we have demonstrated that PGF2alpha activates extracellular signal regulated kinase ( ERK ) mitogen activated protein ( MAP ) kinase signaling through a Raf dependent mechanism in bovine luteal cells
Cain et al., Hypertension 2002 (Coronary Vasospasm) : PGF ( 2alpha ) did not cause any additional increases in tyrosine phosphorylation of MAPK in tissues untreated or pretreated with ET-1 or PMA
Selvaraj et al., Blood 2003 (Anemia, Sickle Cell) : PlGF caused a time dependent transient increase in phosphorylation of extracellular signal regulated kinase-1/2 ( ERK-1/2 ), which was completely inhibited by wortmannin, indicating that activation of PI3 kinase preceded MEK activation ... Overexpression of a dominant negative AKT or a dominant negative PI3 kinase p85 subunit in THP-1 monocytes attenuated the PlGF mediated phosphorylation of ERK-1/2 , cytochemokine secretion, and chemotaxis
Makarevich et al., Exp Clin Endocrinol Diabetes 2004 : The influence of OT on both PKA and MAPK, and the ability of PKA and MAPK blockers to prevent completely or partially OT effects suggest, that effects of OT on PGF and PGE can be mediated by both PKA and MAPK
Arroyo et al., Placenta 2004 : In contrast, PlGF induces strong ERK-1/2 activation, but little JNK or p38 responses in human umbilical vein endothelial cells ( HUVEC )
Teng et al., Am J Physiol Heart Circ Physiol 2005 : Western blot analysis demonstrated that PGF ( 2alpha ) and adenosine agonists stimulated p38 MAPK at a concentration of 40 nM in PCA smooth muscle cells
Meidan et al., Domest Anim Endocrinol 2005 : PGF2alpha activated p42/44 MAPK phosphorylation also in long-term cultured LEC
Knock et al., Am J Physiol Lung Cell Mol Physiol 2005 (Anoxia...) : Western blot analysis revealed that PGF ( 2alpha ) ( 20 microM ) increased phosphorylation of p38 MAPK and of heat shock protein 27 (HSP27), and this was abolished by SB-203580 but not by SB-202474 ( both 2 microM )
Dekanty et al., FEBS Lett 2006 : We demonstrate that PGF2alpha induces extracellular-signal regulated kinase ( ERK1-2 ) and p38MAPK activation, and inhibition of any of these signaling pathways completely blocks PGF2alpha stimulated DNA synthesis
Liagre et al., Int J Mol Med 2007 (Arthritis, Rheumatoid...) : All MAPK inhibitors markedly reduced diosgenin induced PGE2 and 6-keto-PGF1alpha synthesis except for SP600125 on 6-keto-PGF1alpha production
Brooks et al., Vet Immunol Immunopathol 2009 : The effects of the p38 MAPK inhibitors, SB203580 and PD169316, on neutrophil adhesion and 6-keto-PGF ( 1alpha ) release were examined, as was the effect of an anti-E-selectin antibody on neutrophil adhesion to LPS activated EDVEC ... 6-keto-PGF ( 1alpha ) release was increased in a concentration dependent manner following LPS exposure ( maximal at 10 ( -6 ) g/ml ; EC ( 50 ) = 1 x 10 ( -9 ) g/ml ), and was significantly inhibited by p38 MAPK blockade ( reduced from 1.6+/-0.3 x 10 ( -9 ) g/ml to 4+/-1 x 10 ( -10 ) g/ml and 4+/-2 x 10 ( -10 ) g/ml with 10 ( -6 ) M SB203580 or 10 ( -6 ) M PD169316, respectively )
Rice et al., Ann Clin Lab Sci 2010 : These findings suggest that aging does not affect the ability of the rat aorta to activate ERK ( 1/2 ) -, p38-MAPK , and JNK-MAPK phosphorylation in response to PGF2alpha stimulation
Van Steenkiste et al., Hepatology 2011 (Hepatitis...) : Notably, PlGF treatment of activated hepatic stellate cells induced sustained extracellular signal regulated kinase 1/2 phosphorylation, as well as chemotaxis and proliferation, indicating a previously unrecognized profibrogenic role of PlGF
Kwok et al., Gen Comp Endocrinol 2012 : Using a pGL4-SRE reporter system, both cEP ( 3 ) and cFPa exhibited potential MAPK activation by PGE ( 2 ) and PGF ( 2a ) at EC ( 50 ) 0.34 and 13 nM, respectively
Hakeda et al., Endocrinology 1997 : To elucidate intracellular events elicited by this receptor, we examined the effects of PGF2alpha on tyrosine phosphorylation and mitogen activated protein kinase ( MAPK ) activity in MC3T3-E1 cells ... In addition, PGF2alpha augmented the MAPK kinase kinase activity of Raf-1, whereas basal activity of MAPK/extracellular signal regulated protein kinase kinase was less than that of Raf-1 and was little affected by PGF2alpha ... However, the tyrosine kinase inhibitor partially inhibited the MAPK activity, suggesting an involvement of another Raf-1 independent kinase cascade for activation of MAPK by PGF2alpha
Chen et al., Endocrinology 1998 : As determined by hyperphosphorylation, tyrosine phosphorylation, and enzymatic activity, p42mapk and p44mapk were rapidly and transiently activated by both PGF2alpha ( 1 microM ) and PMA ( 20 nM )