Gene interactions and pathways from curated databases and text-mining

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MAPK14 — PGD

Text-mined interactions from Literome

Fernández-Tome et al., Biochem Biophys Res Commun 2004 : PGD ( 2 ) also increased phospho-ERK1/2 MAPK in a biphasic-fashion, which was abolished by PLC and PKC inhibitors but not by ethanol, which overincreased phospho-ERK1/2, suggesting that PGD ( 2 ) -induced ERK1/2 activation requires previous PLC-PKC activation while PLD down-regulates it ... Our results indicate that PGD ( 2 ) stimulatory effect involves both PLD and ERK1/2-MAPK activation, and both pathways operate independently of PC synthesis homeostasis
Moreira et al., Eur J Pharmacol 2013 : Inhibitors of either protein kinase C ( PKC ), protein tyrosine kinase ( PTK ), or extracellular signal regulated kinase ( ERK ) pathways abrogated MT-II induced NF-?B activation and reduced COX-2 expression and PGE2 release, whereas the p38 mitogen activated protein kinase ( MAPK ) inhibitor reduced MT-II induced COX-2 expression and PGD2 production