Gene interactions and pathways from curated databases and text-mining

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CREB1 — PGC

Text-mined interactions from Literome

Herzig et al., Nature 2001 (Diabetes Mellitus, Experimental...) : Fasting hyperglycaemia is strongly correlated with type II diabetes, so our results suggest that the activation of PGC-1 by CREB in liver contributes importantly to the pathogenesis of this disease
Herzig et al., Nature 2003 (Fatty Liver) : The coordinate induction of PGC-1 and repression of PPAR-gamma by CREB during fasting provides a molecular rationale for the antagonism between insulin and counter-regulatory hormones, and indicates a potential role for CREB antagonists as therapeutic agents in enhancing insulin sensitivity in the liver
Mehta et al., Int J Biochem Cell Biol 2013 : Similarly, CREB inhibition reduced CREB activation and PGC-1a protein levels in selenoprotein H transfected cells
Zuo et al., Biochem Biophys Res Commun 2013 (Intermittent Claudication) : Moreover, the increased expression of PGC-1a induced by cilostazol could be inhibited by downregulation of CREB using CREB siRNA at both mRNA and protein levels