Gene interactions and pathways from curated databases and text-mining

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AKT1 — PFN1

Text-mined interactions from Literome

Das et al., J Cell Physiol 2009 (Breast Neoplasms) : Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells ... We found that even a moderate overexpression of Pfn1 leads to a significant reduction in phosphorylation of AKT in MDA-MB-231 breast cancer cells
Jin et al., PloS one 2012 (Inflammation) : Our findings reveal that ACE2 deficiency worsens Ang II-mediated aortic inflammation and peroxynitrite production associated with the augmentation of profilin-1 expression and the activation of the Akt-ERK-eNOS signaling, suggesting potential therapeutic approaches by enhancing ACE2 action for patients with vascular diseases