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AKT1 — PFN1
Text-mined interactions from Literome
Das et al., J Cell Physiol 2009
(Breast Neoplasms) :
Profilin-1 overexpression upregulates PTEN and
suppresses AKT activation in breast cancer cells ... We found that even a moderate overexpression of
Pfn1 leads to a significant reduction in phosphorylation of
AKT in MDA-MB-231 breast cancer cells
Jin et al., PloS one 2012
(Inflammation) :
Our findings reveal that ACE2 deficiency worsens Ang II-mediated aortic inflammation and peroxynitrite production associated with the augmentation of
profilin-1 expression and the
activation of the
Akt-ERK-eNOS signaling, suggesting potential therapeutic approaches by enhancing ACE2 action for patients with vascular diseases