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AKT1 — PECAM1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
PECAM1
→
AKT1
(increases, PECAM1 Activity)
Evidence: the expressions of KDR and CD31 were sharply enhanced in Akt-CA EPCs
Text-mined interactions from Literome
Limaye et al., Blood 2005
:
Sphingosine kinase-1 enhances endothelial cell survival through a
PECAM-1 dependent activation of
PI-3K/Akt and regulation of Bcl-2 family members
Tai et al., J Biol Chem 2005
:
Tie2 and
PECAM1 expression decreased > 80 % after siRNA treatment, and flow stimulated phosphorylation of ERK1/2,
Akt , and endothelial nitric oxide synthase was significantly
inhibited by Tie2 and PECAM1 siRNA
Fleming et al., J Cell Sci 2005
:
Role of
PECAM-1 in the shear-stress induced activation of
Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells ... Down-regulation of
PECAM-1 using a siRNA approach
attenuated the shear-stress induced phosphorylation of
Akt and eNOS, as well as the shear-stress induced accumulation of cyclic GMP levels while the shear-stress induced phosphorylation of AMPK remained intact
Chen et al., Arterioscler Thromb Vasc Biol 2009
(Coronary Restenosis...) :
Inward remodeling was associated with
PECAM-1 dependent NFkappaB activation, surface adhesion molecule expression, and leukocyte infiltration as well as
Akt activation and vascular cell proliferation
He et al., Cancer Chemother Pharmacol 2013
(Carcinoma, Non-Small-Cell Lung...) :
EGCG inhibited HPV-16 oncoprotein induced angiogenesis conferred by NSCLC through the inhibition of HIF-1a protein expression and HIF-1a dependent expression of VEGF, IL-8, and
CD31 as well as
activation of
Akt , suggesting that HIF-1a may be a potential target of EGCG against HPV related NSCLC angiogenesis