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AKT1 — PEBP4
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Li et al., J Biol Chem 2007
(Breast Neoplasms...) :
Interestingly,
hPEBP4 overexpression in TRAIL-sensitive DU145 cells
promoted Akt activation but inhibited ERK1/2 activation ... In contrast, silencing of
hPEBP4 in TRAIL-resistant LNCaP cells
inhibited Akt activation but increased ERK1/2 activation, resulting in their sensitivity to TRAIL induced apoptosis that was restored by the MEK1 inhibitor ... Therefore,
hPEBP4 expression in prostate cancer can
activate Akt and deactivate ERK1/2 signaling, leading to TRAIL resistance
Qiu et al., J Biol Chem 2010
(Breast Neoplasms...) :
We further demonstrated that IOI-42 could reduce the endogenous association of
hPEBP4 with Raf-1/MEK1 and
enhance the activation of ERK1/2 and JNK while inhibiting
Akt activation