Gene interactions and pathways from curated databases and text-mining

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MAPK3 — PDLIM7

Text-mined interactions from Literome

Schultheiss et al., EMBO J 2001 (Cell Transformation, Viral...) : In TRAF6-knockout fibroblasts, significant induction of p38 MAPK by LMP1 is dependent on the ectopic expression of TRAF6
Fukuda et al., Virology 2002 (Cell Transformation, Neoplastic...) : EBV latent membrane protein 1 (LMP1) induced constitutive ERK 1/2 phosphorylation and NF-kappa B activation in LMP1 transfected HSC-39 cells, which then became resistant to TGF-beta 1-mediated growth inhibition, TGF-beta 1-mediated ERK 1/2 phosphorylation, and p21 induction, and proliferated in low-serum medium ... These results are consistent with the conclusion that the TGF-beta 1/MAPK/p21 pathway is required for TGF-beta 1-mediated growth inhibition, and that the resistance to TGF in GT38 cells is derived from constitutive MAPK phosphorylation induced by LMP1
Everly et al., J Virol 2004 (Cell Transformation, Viral) : Latent membrane protein 1 (LMP1) , the Epstein-Barr virus oncoprotein, activates NF-kappaB, phosphatidylinositol 3-kinase, mitogen activated protein kinase , and c-Jun N-terminal kinase signaling