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AKT1 — PDK4
Text-mined interactions from Literome
Wen et al., Cell Signal 2003
:
The increased
Akt phosphorylation was
blocked by phosphatidylinositol 3-kinase inhibitor wortmannin and the newly identified PIP ( 3 ) -dependent kinases (
PDK ) inhibitor SB 203580
Zou et al., Sheng li ke xue jin zhan [Progress in physiology] 2000
:
PKB is also
activated via phosphorylation by
PDK and, in turn, will activate the anti-apoptotic machinery, glucose metabolism ( glycogen synthesis, glycolysis and glucose uptake ) and protein synthesis
Thimmaiah et al., J Biol Chem 2005
:
Akt inhibitory phenoxazines did not inhibit the activity of recombinant phosphatidylinositol 3'-kinase,
PDK1 , or SGK1 but potently
inhibited the kinase activity of recombinant
Akt and Akt deltaPH, a mutant lacking the pleckstrin homology domain
Zhang et al., Biochem Pharmacol 2007
(Prostatic Neoplasms) :
In PC-3 cells, CMEP has been found to inhibit only
AKT activation at both normal and serum-starvation conditions, not to
inhibit PI3K,
PDK1 , or MAPK
Lee et al., Mol Biol Cell 2009
(Alzheimer Disease) :
In vitro experiments identified that beta-amyloid ( Abeta ), especially oligomer preparations, specifically interrupted the
PDK dependent activation of
Akt