Gao et al., J Biol Chem 2005
(Wounds and Injuries) :
These results indicate that disruption of distinct PDGFR-beta signaling pathways in PDGFR-betaDelta/Delta dermal fibroblasts impaired their proliferation and survival, but completely inhibits migratory response, and that PDGF-BB induced phosphorylation of Akt and ERK1/2 possibly mediated by PDGFR-alpha is regulated, at least in part, by the lipid phosphatases SHIP2 and/or PTEN
Peterson et al., Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2006
(Abdominal Neoplasms...) :
Phosphorylated AKT positivity was not associated with the immunoreactivity or mutation of PDGFRA and c-kit, suggesting that the activation of AKT is probably independent of the activation of PDGFRA and c-kit in GISTs
Buitenhuis et al., Cancer Res 2007
(Chronic Disease...) :
FIP1L1-PDGFRA and FIP1L1 ( 1-29 ) -PDGFRA both induced the activation of p38 and extracellular signal regulated kinase 1/2 ( ERK1/2 ) in myeloid progenitors, whereas signal transducers and activators of transcription 5 ( STAT5 ) and protein kinase B/c-akt were only activated by FIP1L1-PDGFRA