Gene interactions and pathways from curated databases and text-mining

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MAPK3 — PDGFB

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Hanada et al., Biol Pharm Bull 1999 : PDGF-AB stimulated mitogen activated protein ( MAP ) kinases , and PDGF induced MAP kinase activation was inhibited by genistein
Yoshimata et al., Life Sci 1999 : Only MAPK activation induced by PDGF-BB was reduced by pretreatment with DHEA, although DHEA did not affect the MAPK activation induced by EGF or bFGF ... These results suggest that DHEA inhibited MAPK activation induced by PDGF-BB via PGE2 overproduction and subsequent cAMP dependent pathway in human male aortic SMCs
Shimizu et al., Cardiovasc Res 1999 : PDGF-BB also induced tyrosine phosphorylation and nuclear translocation of MAPK
Yang et al., Cell Signal 2000 : Furthermore, we also showed that overexpression of dominant negative mutants of Ras ( RasN17 ) and Raf ( Raf-301 ) completely suppressed MEK1/2 and p42/p44 MAPK activation induced by OX-LDL and PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Luo et al., Br J Pharmacol 2000 : Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44 MAPK activation induced by LPS and PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Yang et al., Br J Pharmacol 2001 (MAP Kinase Signaling System) : 7. Overexpression of dominant negative mutants of Ras ( H-Ras-15A ) and Raf ( Raf-N4 ) significantly suppressed MEK1/2 and p42/p44 MAPK activation induced by OX-LDL and PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Lin et al., Cell Signal 2001 (MAP Kinase Signaling System) : Furthermore, overexpression of dominant negative mutants, RasN17 and Raf-301, significantly suppressed p42/p44 MAPK activation induced by thrombin and PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Shearer et al., Exp Eye Res 2001 (MAP Kinase Signaling System) : Pretreatment with U0126 or chelerythrine significantly reduced ERK 1/2 activation induced by PDGF-BB or PMA ... In trabecular meshwork cells, PDGF-BB and PMA activate ERK 1/2 by a PKC dependent mechanism
Hsu et al., Cell Signal 2001 (MAP Kinase Signaling System) : Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44 mitogen activated protein kinase ( MAPK ) activation induced by TNF-alpha and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response, indicating that Ras and Raf may be required for activation of these kinases
Cartel et al., Am J Physiol Lung Cell Mol Physiol 2001 (MAP Kinase Signaling System) : PDGF-BB mediated activation of p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation ... Chemical inhibition of Janus kinase, phosphatidylinositol 3-kinase, Src kinase, or tyrosine phosphorylation inhibition of the PDGF beta-receptor ( PDGFR-beta ) did not abrogate PDGF-BB induced p42(MAPK) activation or its threonine or tyrosine phosphorylation ... A dominant negative cytoplasmic receptor for hyaluronan mediated motility variant 4 ( RHAMMv4 ), a regulator of MAPKK-MAPK interaction and activation, did not inhibit PDGF-BB induced p42(MAPK) activation nor did a construct expressing PDGFR-beta with cytoplasmic tyrosines mutated to phenylalanine ... These results suggest that PDGF-BB mediated activation of p42(MAPK) requires the PDGFR-beta but is independent of its tyrosine phosphorylation
Ricono et al., American journal of physiology. Renal physiology 2002 (MAP Kinase Signaling System) : PDGF AA and PDGF BB significantly increased the activities of phosphatidylinositol 3-kinase (PI 3-K) and mitogen activated protein kinase ( MAPK )
Lin et al., Cell Signal 2002 (MAP Kinase Signaling System) : Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44 MAPK activation induced by thrombin and PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
De Marchis et al., Blood 2002 : In addition, PDGF-Ralpha phosphorylation was increased in the presence of bFGF and PDGF, as compared to PDGF alone, whereas mitogen activated protein kinase phosphorylation was decreased in the presence of PDGF-BB and bFGF compared with bFGF alone
Rolny et al., J Biol Chem 2002 : Heparin potentiated PDGF-BB induced activation of mitogen activated protein kinase and protein kinase B ( Akt ) and allowed increased chemotaxis of the CHO 677 cells toward PDGF-BB
Ghosh et al., J Biol Chem 2002 : Platelet derived growth factor (PDGF)-BB and thrombin ( RTK and GPCR agonists, respectively ) activated p38 MAPK in a time dependent manner in VSMC
Liu et al., Surgery 2002 : In contrast, C3 did not significantly affect DNA synthesis in response to PDGF-AB or activation of mitogen activated protein kinase , a signaling mediator of PDGF stimulated proliferation
Yang et al., Cell Signal 2002 (Asthma...) : Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44 MAPK activation induced by SP and PDGF-BB
Kotsuji-Maruyama et al., J Dermatol 2002 (Neurofibromatosis 1) : PDGF-BB furthermore induced the mitogen activated protein kinase phosphorylation in NF-derived cells from patients with NF1
Oak et al., Arterioscler Thromb Vasc Biol 2003 (MAP Kinase Signaling System) : Short-term and long-term treatment of VSMCs with RWPCs markedly reduced PDGFAB induced production of reactive oxygen species and phosphorylation of p38 MAPK
Zhang et al., Biochem Pharmacol 2003 : FAN significantly inhibited both 5 % fetal bovine serum ( FBS ) - and 50ng/mL platelet derived growth factor (PDGF)-BB induced proliferation, [ 3H ] thymidine incorporation into DNA and phosphorylation of extracellular signal regulated kinase 1/2
Ling et al., J Cardiovasc Pharmacol 2004 : Immunoprecipitation assays revealed that cis-THD inhibited PDGF BB-stimulated activation of mitogen activated protein ( MAP ) kinase ERK-1 by 34 % at 1 nmol/L, 58 % at 10 nmol/L, and 81 % at 100 nmol/L, while MAP kinase JNK and p38 activities were unaltered
Gao et al., J Biol Chem 2005 (Wounds and Injuries) : Concerning the PDGF signaling, PDGF-BB induced phosphorylation of Akt, ERK1/2 , and JNK, but not p38, decreased in PDGFR-betaDelta/Delta fibroblasts, but PDGF-AA induced signaling was not altered
Kim et al., Biochem Pharmacol 2005 : Pre-incubation of rat aortic VSMCs with luteolin significantly inhibited the PDGF-BB induced extracellular signal regulated kinase 1/2 ( ERK1/2 ), Akt and phospholipase C (PLC)-gamma1 activation as well as c-fos gene expression
Ohkawara et al., Eur J Pharmacol 2005 : Astrapterocarpan inhibited PDGF-BB induced phosphorylation of extracellular signal regulated kinase 1/2 ( ERIC1/2 ) mitogen activated protein ( MAP ) kinase
Kim et al., Arch Pharm Res 2006 : Pre-incubation of the VSMCs with L7G significantly inhibited the PDGF-BB induced extracellular signal regulated kinase 1/2 ( ERK1/2 ), Akt and the phospholipase C (PLC)-gamma1 activation
Rousseau et al., Cell Signal 2006 (MAP Kinase Signaling System) : Here we show that CXCL12, complement factor 5a ( C5a ), hepatocyte growth factor (HGF) and platelet derived growth factor (PDGF)-BB , which stimulate cell migration, also activate p38alpha MAPK
Muhl et al., Biochem J 2007 : This leads to the loss of the inhibitory effect of FSAP on PDGF-BB mediated DNA synthesis and mitogen activated protein kinase phosphorylation in VSMCs
Lee et al., Cardiovasc Res 2007 (MAP Kinase Signaling System) : PDGF-BB increased the phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, p38 MAPK , and HSP27, which were significantly inhibited by piceatannol and in Syk-knockdown cells
Chiang et al., Life Sci 2007 (Melanoma) : PDGF-BB induced phosphorylation of PDGF receptor beta ( PDGFR-beta ), extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38, and c-Jun N-terminal kinase (JNK) was attenuated by lycopene in a concentration dependent manner, whereas the total expression of each protein was not affected
Liu et al., Mol Biol Cell 2008 : SMOC-2 ablation did not inhibit PDGF induced PDGFbetaR autophosphorylation or PDGF-BB dependent activation of mitogen activated protein kinase and Akt kinases, suggesting that SMOC-2 is dispensable for growth factor receptor activation
Seo et al., Biochem Pharmacol 2008 : JM91 inhibited the PDGF-BB stimulated phosphorylation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and Akt kinase, while had no effect on PLCgamma1 and PDGF-Rbeta activation
Jiang et al., Chem Biol Interact 2008 : Preincubation of RASMCs with 9 microM PNN resulted in a significant inhibition of PDGF-BB induced extracellular signal regulated kinase1/2 ( ERK1/2 ) phosphorylation expression and PDGF-BB induced CREB phosphorylation expression
Lamy et al., Carcinogenesis 2008 (Neovascularization, Pathologic) : The inhibitory effect of delphinidin on PDGFR-beta was very rapid and led to the inhibition of PDGF-BB induced activation of extracellular signal regulated kinase ( ERK)-1/2 signaling and of the chemotactic motility of SMC, as well as the differentiation and stabilization of EC and SMC into capillary-like tubular structures in a three-dimensional coculture system
Wu et al., Pharmacol Res 2009 (MAP Kinase Signaling System) : FBS- and PDGF-BB stimulated intracellular Ras, MEK1/2, ERK1/2 , proliferative cell nuclear antigen ( PCNA ), and Akt activations were significantly inhibited by lercanidipine ; however, lercanidipine did not affect FBS- and PDGF-BB induced STAT3 phosphorylation
Roderfeld et al., Liver Int 2009 (Liver Cirrhosis) : FSAP inhibited PDGF-BB stimulated p42/p44 MAPK phosphorylation, proliferation and migration of HSC
Choi et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2009 : The effects of PDGF-BB induced extracellular signal regulated kinase1/2 was not altered by the olibanum extract
Chan et al., Molecular vision 2010 : Furthermore, EGCG is shown to suppress PDGF-BB induced PDGF-beta receptors, downstream PI3K/Akt, and MAPK phosphorylation
Tomkowicz et al., Cancer Biol Ther 2010 : However, when TEM-1 expression was knocked-down, PDGF-BB induced proliferation, ERK-1/2 phosphorylation, and c-Fos expression were significantly impaired
Seidel et al., Respir Res 2010 (Airway Remodeling) : PDGF-BB induced the phosphorylation of ERK1/2 and p38 MAPK , but not of JNK ... DMF enhanced the PDGF-BB induced phosphorylation of p38 MAPK and there by up-regulated the expression of HO-1
Zhong et al., Lung Cancer 2011 (Mesothelioma...) : PDGF-BB induced proliferation was suppressed by down-regulation of either Erk1/2, or p38d MAPK , or C/EBP-a ... PDGF-BB induced proliferation was suppressed by down-regulation of either Erk1/2 , or p38d MAPK, or C/EBP-a
Zhu et al., Mol Cell Biochem 2013 (MAP Kinase Signaling System...) : The activations of mitogen activated protein kinase extracellular signal regulated kinases, Akt, GSK3ß and STAT3 induced by PDGF-BB were also inhibited in sinomenine treated VSMCs
Lubinus et al., J Biol Chem 1994 : We investigated the effects of platelet derived growth factor (PDGF) AA and PDGF BB on activation of MAPK in human dermal fibroblasts, and asked whether its activation correlates with proliferative responses of human fibroblasts to PDGF AA and PDGF BB ... Thus both PDGF AA and PDGF BB are potent activators of MAPK in human dermal fibroblasts
Mallat et al., J Clin Invest 1995 (Liver Cirrhosis) : Analysis of the intermediate steps leading to growth-inhibition by ET-1 revealed that activation of mitogen activated protein kinase by serum or PDGF-BB was decreased by 50 % in the presence of SRTX-C
Graves et al., Proc Natl Acad Sci U S A 1993 : Stimulation of aortic smooth muscle cells with platelet derived growth factor BB homodimer ( PDGF-BB ) leads to the rapid activation of mitogen activated protein kinase ( MAPK ) and MAPK kinase ( MAPKK ) ... Compounds that increase cAMP and activate protein kinase A (PKA) -- prostaglandin E2, isoproterenol, cholera toxin, and forskolin -- were found to inhibit the PDGF-BB induced activation of MAPKK and MAPK ... Forskolin, but not the inactive analogue 1,9-dideoxyforskolin, inhibited PDGF-BB stimulated MAPKK and MAPK activation in a dose dependent manner
Huwiler et al., Biochem J 1995 : Whereas stimulation with PDGF-BB caused a potent and sustained ( for more than 30 min ) phosphorylation and activation of p42mapk and p44mapk , as well as of the upstream activators MAP kinase kinase and c-Raf, the effect of angiotensin II was less potent, reaching a peak at 5-10 min and thereafter declining rapidly
Schramek et al., J Cardiovasc Pharmacol 1995 : Cycloheximide ( 10 micrograms/ml ) inhibited MEK-1 mRNA induction but stimulated p42 MAPK mRNA expression in both the absence and the presence of ET-1 and/or PDGF BB
Graf et al., Hypertension 1997 : Using an in-gel kinase assay, we observed that PD 98059 an inhibitor of MEK that activates MAP kinase, inhibited PDGF-BB induced activation of ERK-1 and ERK-2 in cultured rat aortic smooth muscle cells in a concentration dependent manner
Chaudhary et al., Biochem Biophys Res Commun 1997 : Results have demonstrated that in addition to ERK2, ERK1 is activated by FGF-2 and PDGF-BB in normal HOB and HBMS cells
Seewald et al., J Hypertens 1997 : PDGF-BB induces an increase in intracellular free calcium concentration ( [ Ca2+ ] i ), an activation of mitogen activated protein ( MAP ) kinase and an increase in DNA synthesis
Hinton et al., Exp Cell Res 1998 : Using transwell cell-culture chambers, the effect of PDGF-BB ( 10-50 ng/ml ) and fibronectin on components of migration was measured with or without the MAPK pathway inhibitor PD98059 ( 10-30 microM ) MAPK activation of serum starved cells by PDGF-BB was demonstrated by an immunoprecipitation/kinase assay and by immunohistochemistry using antibody specific for phosphorylated MAPK ... PDGF-BB ( 10 ng/ml ) stimulated MAPK activity in RPE ( 10 min ) and its nuclear localization ( 1 h ) ... PD98059 inhibited the activation of MAPK by PDGF-BB or serum