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MAPK14 — PDGFB

Text-mined interactions from Literome

Hanada et al., Biol Pharm Bull 1999 : PDGF-AB stimulated mitogen activated protein ( MAP ) kinases , and PDGF induced MAP kinase activation was inhibited by genistein
Yoshimata et al., Life Sci 1999 : Only MAPK activation induced by PDGF-BB was reduced by pretreatment with DHEA, although DHEA did not affect the MAPK activation induced by EGF or bFGF ... These results suggest that DHEA inhibited MAPK activation induced by PDGF-BB via PGE2 overproduction and subsequent cAMP dependent pathway in human male aortic SMCs
Shimizu et al., Cardiovasc Res 1999 : PDGF-BB also induced tyrosine phosphorylation and nuclear translocation of MAPK
Yang et al., Cell Signal 2000 : Furthermore, we also showed that overexpression of dominant negative mutants of Ras ( RasN17 ) and Raf ( Raf-301 ) completely suppressed MEK1/2 and p42/p44 MAPK activation induced by OX-LDL and PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Luo et al., Br J Pharmacol 2000 : Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44 MAPK activation induced by LPS and PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Yang et al., Br J Pharmacol 2001 (MAP Kinase Signaling System) : 7. Overexpression of dominant negative mutants of Ras ( H-Ras-15A ) and Raf ( Raf-N4 ) significantly suppressed MEK1/2 and p42/p44 MAPK activation induced by OX-LDL and PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Lin et al., Cell Signal 2001 (MAP Kinase Signaling System) : Furthermore, overexpression of dominant negative mutants, RasN17 and Raf-301, significantly suppressed p42/p44 MAPK activation induced by thrombin and PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
Hsu et al., Cell Signal 2001 (MAP Kinase Signaling System) : Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44 mitogen activated protein kinase ( MAPK ) activation induced by TNF-alpha and PDGF-BB and attenuated the effect of TNF-alpha on BK-induced IP response, indicating that Ras and Raf may be required for activation of these kinases
Cartel et al., Am J Physiol Lung Cell Mol Physiol 2001 (MAP Kinase Signaling System) : PDGF-BB mediated activation of p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation ... Chemical inhibition of Janus kinase, phosphatidylinositol 3-kinase, Src kinase, or tyrosine phosphorylation inhibition of the PDGF beta-receptor ( PDGFR-beta ) did not abrogate PDGF-BB induced p42(MAPK) activation or its threonine or tyrosine phosphorylation ... A dominant negative cytoplasmic receptor for hyaluronan mediated motility variant 4 ( RHAMMv4 ), a regulator of MAPKK-MAPK interaction and activation, did not inhibit PDGF-BB induced p42(MAPK) activation nor did a construct expressing PDGFR-beta with cytoplasmic tyrosines mutated to phenylalanine ... These results suggest that PDGF-BB mediated activation of p42(MAPK) requires the PDGFR-beta but is independent of its tyrosine phosphorylation
Ricono et al., American journal of physiology. Renal physiology 2002 (MAP Kinase Signaling System) : PDGF AA and PDGF BB significantly increased the activities of phosphatidylinositol 3-kinase (PI 3-K) and mitogen activated protein kinase ( MAPK )
Lin et al., Cell Signal 2002 (MAP Kinase Signaling System) : Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44 MAPK activation induced by thrombin and PDGF-BB , indicating that Ras and Raf may be required for activation of these kinases
De Marchis et al., Blood 2002 : In addition, PDGF-Ralpha phosphorylation was increased in the presence of bFGF and PDGF, as compared to PDGF alone, whereas mitogen activated protein kinase phosphorylation was decreased in the presence of PDGF-BB and bFGF compared with bFGF alone
Rolny et al., J Biol Chem 2002 : Heparin potentiated PDGF-BB induced activation of mitogen activated protein kinase and protein kinase B ( Akt ) and allowed increased chemotaxis of the CHO 677 cells toward PDGF-BB
Ghosh et al., J Biol Chem 2002 : Platelet derived growth factor (PDGF)-BB and thrombin ( RTK and GPCR agonists, respectively ) activated p38 MAPK in a time dependent manner in VSMC
Liu et al., Surgery 2002 : In contrast, C3 did not significantly affect DNA synthesis in response to PDGF-AB or activation of mitogen activated protein kinase , a signaling mediator of PDGF stimulated proliferation
Yang et al., Cell Signal 2002 (Asthma...) : Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44 MAPK activation induced by SP and PDGF-BB
Kotsuji-Maruyama et al., J Dermatol 2002 (Neurofibromatosis 1) : PDGF-BB furthermore induced the mitogen activated protein kinase phosphorylation in NF-derived cells from patients with NF1
Oak et al., Arterioscler Thromb Vasc Biol 2003 (MAP Kinase Signaling System) : Short-term and long-term treatment of VSMCs with RWPCs markedly reduced PDGFAB induced production of reactive oxygen species and phosphorylation of p38 MAPK
Rousseau et al., Cell Signal 2006 (MAP Kinase Signaling System) : Here we show that CXCL12, complement factor 5a ( C5a ), hepatocyte growth factor (HGF) and platelet derived growth factor (PDGF)-BB , which stimulate cell migration, also activate p38alpha MAPK
Muhl et al., Biochem J 2007 : This leads to the loss of the inhibitory effect of FSAP on PDGF-BB mediated DNA synthesis and mitogen activated protein kinase phosphorylation in VSMCs
Lee et al., Cardiovasc Res 2007 (MAP Kinase Signaling System) : PDGF-BB increased the phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, p38 MAPK , and HSP27, which were significantly inhibited by piceatannol and in Syk-knockdown cells
Liu et al., Mol Biol Cell 2008 : SMOC-2 ablation did not inhibit PDGF induced PDGFbetaR autophosphorylation or PDGF-BB dependent activation of mitogen activated protein kinase and Akt kinases, suggesting that SMOC-2 is dispensable for growth factor receptor activation
Roderfeld et al., Liver Int 2009 (Liver Cirrhosis) : FSAP inhibited PDGF-BB stimulated p42/p44 MAPK phosphorylation, proliferation and migration of HSC
Chan et al., Molecular vision 2010 : Furthermore, EGCG is shown to suppress PDGF-BB induced PDGF-beta receptors, downstream PI3K/Akt, and MAPK phosphorylation
Seidel et al., Respir Res 2010 (Airway Remodeling) : PDGF-BB induced the phosphorylation of ERK1/2 and p38 MAPK , but not of JNK ... DMF enhanced the PDGF-BB induced phosphorylation of p38 MAPK and there by up-regulated the expression of HO-1
Zhong et al., Lung Cancer 2011 (Mesothelioma...) : PDGF-BB induced proliferation was suppressed by down-regulation of either Erk1/2, or p38d MAPK , or C/EBP-a
Zhu et al., Mol Cell Biochem 2013 (MAP Kinase Signaling System...) : The activations of mitogen activated protein kinase extracellular signal regulated kinases, Akt, GSK3ß and STAT3 induced by PDGF-BB were also inhibited in sinomenine treated VSMCs
Lubinus et al., J Biol Chem 1994 : We investigated the effects of platelet derived growth factor (PDGF) AA and PDGF BB on activation of MAPK in human dermal fibroblasts, and asked whether its activation correlates with proliferative responses of human fibroblasts to PDGF AA and PDGF BB ... Thus both PDGF AA and PDGF BB are potent activators of MAPK in human dermal fibroblasts
Mallat et al., J Clin Invest 1995 (Liver Cirrhosis) : Analysis of the intermediate steps leading to growth-inhibition by ET-1 revealed that activation of mitogen activated protein kinase by serum or PDGF-BB was decreased by 50 % in the presence of SRTX-C
Graves et al., Proc Natl Acad Sci U S A 1993 : Stimulation of aortic smooth muscle cells with platelet derived growth factor BB homodimer ( PDGF-BB ) leads to the rapid activation of mitogen activated protein kinase ( MAPK ) and MAPK kinase ( MAPKK ) ... Compounds that increase cAMP and activate protein kinase A (PKA) -- prostaglandin E2, isoproterenol, cholera toxin, and forskolin -- were found to inhibit the PDGF-BB induced activation of MAPKK and MAPK ... Forskolin, but not the inactive analogue 1,9-dideoxyforskolin, inhibited PDGF-BB stimulated MAPKK and MAPK activation in a dose dependent manner
Schramek et al., J Cardiovasc Pharmacol 1995 : Cycloheximide ( 10 micrograms/ml ) inhibited MEK-1 mRNA induction but stimulated p42 MAPK mRNA expression in both the absence and the presence of ET-1 and/or PDGF BB
Seewald et al., J Hypertens 1997 : PDGF-BB induces an increase in intracellular free calcium concentration ( [ Ca2+ ] i ), an activation of mitogen activated protein ( MAP ) kinase and an increase in DNA synthesis
Hinton et al., Exp Cell Res 1998 : Using transwell cell-culture chambers, the effect of PDGF-BB ( 10-50 ng/ml ) and fibronectin on components of migration was measured with or without the MAPK pathway inhibitor PD98059 ( 10-30 microM ) MAPK activation of serum starved cells by PDGF-BB was demonstrated by an immunoprecipitation/kinase assay and by immunohistochemistry using antibody specific for phosphorylated MAPK ... PDGF-BB ( 10 ng/ml ) stimulated MAPK activity in RPE ( 10 min ) and its nuclear localization ( 1 h ) ... PD98059 inhibited the activation of MAPK by PDGF-BB or serum