Gene interactions and pathways from curated databases and text-mining

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AKT1 — PDGFB

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Rauch et al., FEBS Lett 2000 : The present study investigates the role of Akt in the activation of NF-kappa B by tumor necrosis factor-alpha ( TNF alpha, 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells ( SMC ), skin and foreskin fibroblasts
Chaudhary et al., J Cell Biochem 2001 : The cell survival signal Akt is differentially activated by PDGF-BB , EGF, and FGF-2 in osteoblastic cells ... In this study we have investigated the signaling pathways activated by growth factors PDGF-BB, EGF, and FGF-2 and determined whether PDGF-BB , EGF, and FGF-2 activated Akt in human or mouse osteoblastic cells ... Akt activation by PDGF-BB was inhibited by PI 3-kinase inhibitor LY294002 ... Taken together, our data for the first time revealed that the activation of ERK1/2 by PDGF-BB is mediated by PI 3-K, and secondly, Akt is activated by PDGF-BB and EGF but not by FGF-2 in human and mouse osteoblastic cells
Cartel et al., Biochem J 2002 : The PI-3K inhibitor wortmannin blocked PDGF-BB induced Akt activity as well as significantly diminishing PDGF-BB mediated GAG synthesis
Rolny et al., J Biol Chem 2002 : Heparin potentiated PDGF-BB induced activation of mitogen activated protein kinase and protein kinase B ( Akt ) and allowed increased chemotaxis of the CHO 677 cells toward PDGF-BB
Yellaturu et al., J Biol Chem 2002 : PDGF-BB stimulated Akt phosphorylation predominantly at Ser-473 ... N-Ethylmaleimide ( NEM ), a thiol alkylating agent, blocked PDGF-BB induced Akt phosphorylation without affecting its upstream phosphatidylinositol 3-kinase (PI3K) ... On the other hand, LY294002 and wortmannin, specific inhibitors of PI3K, prevented PDGF-BB induced phosphorylation of Akt and its downstream effector molecules, p70S6K, ribosomal protein S6, 4E-BP1, and eIF4E ... The inhibition of PDGF-BB induced Akt phosphorylation by NEM was completely reversed by PP2A inhibitors fostriecin and okadaic acid, ceramide synthase inhibitor fumonisin B1, and ROS scavenger N-acetylcysteine (NAC)
Zhang et al., FASEB J 2003 : Although exogenous PDGF-BB induced only transient Akt activation, hypoxia triggered persistent activation of Akt for up to 24 h. Inhibition of phosphatidylinositol 3-kinase (PI3K) or of PDGF-beta receptor phosphorylation abrogated both hypoxia induced and exogenous PDGF-BB induced Akt phosphorylation, and it completely abolished hypoxia induced protection from media supplement deprivation, which suggests that the long lasting activation of Akt during hypoxia and the prosurvival induction were due to endogenously generated PDGF-BB
Hua et al., Cytokine 2004 : PDGF-BB , but not IL-4, induced STAT3 tyrosine and AKT serine phosphorylation
Gao et al., J Biol Chem 2005 (Wounds and Injuries) : Concerning the PDGF signaling, PDGF-BB induced phosphorylation of Akt , ERK1/2, and JNK, but not p38, decreased in PDGFR-betaDelta/Delta fibroblasts, but PDGF-AA induced signaling was not altered ... Overexpression of the phospholipid phosphatases, SHIP2 and/or PTEN, inhibited PDGF-BB induced phosphorylation of Akt and ERK1/2 in PDGFR-betaDelta/Delta fibroblasts but did not affect that of JNK and p38 ... These results indicate that disruption of distinct PDGFR-beta signaling pathways in PDGFR-betaDelta/Delta dermal fibroblasts impaired their proliferation and survival, but completely inhibits migratory response, and that PDGF-BB induced phosphorylation of Akt and ERK1/2 possibly mediated by PDGFR-alpha is regulated, at least in part, by the lipid phosphatases SHIP2 and/or PTEN
Kim et al., Biochem Pharmacol 2005 : Pre-incubation of rat aortic VSMCs with luteolin significantly inhibited the PDGF-BB induced extracellular signal regulated kinase 1/2 ( ERK1/2 ), Akt and phospholipase C (PLC)-gamma1 activation as well as c-fos gene expression
Hsieh et al., J Clin Invest 2006 : PDGF-BB induced cardiomyocyte Akt phosphorylation in a time- and dose dependent manner and prevented apoptosis via PI3K/Akt signaling ... PDGF-BB with nanofibers induced PDGFR-beta and Akt phosphorylation in cardiomyocytes in vivo
Son et al., J Pharmacol Exp Ther 2006 : In further investigations, melittin markedly inhibited the PDGF-BB induced phosphorylation of Akt and weakly inhibited phosphorylation of extracellular signal regulated kinase 1/2, upstream signals of NF-kappaB
Kim et al., Arch Pharm Res 2006 : Pre-incubation of the VSMCs with L7G significantly inhibited the PDGF-BB induced extracellular signal regulated kinase 1/2 ( ERK1/2 ), Akt and the phospholipase C (PLC)-gamma1 activation
Hanai et al., J Cell Biochem 2006 : PDGF-BB markedly induced the phosphorylation of Akt and GSK-3beta ... Wortmannin and LY294002 suppressed the PDGF-BB induced phosphorylation of Akt and GSK-3beta
Risinger et al., J Biol Chem 2006 : Both PDGF-BB and IGF-I activated PI3K/Akt to similar degrees ; however, only PDGF-BB concomitantly stimulated an inhibitory signaling pathway that antagonized the effects of Akt but did not alter the extent or duration of Akt activation
Han et al., Planta Med 2007 : Cudraflavanone A ( 0.1-1 microM ) suppressed PDGF-BB stimulated Akt activation, which is involved in cell survival, but had no effect on the activation of ERK1/2 and PLCgamma1
Wu et al., Pharmacol Res 2009 (MAP Kinase Signaling System) : FBS- and PDGF-BB stimulated intracellular Ras, MEK1/2, ERK1/2, proliferative cell nuclear antigen ( PCNA ), and Akt activations were significantly inhibited by lercanidipine ; however, lercanidipine did not affect FBS- and PDGF-BB induced STAT3 phosphorylation
Takai et al., Mediators Inflamm 2008 : Finally, the PDGF-BB induced phosphorylation of Akt and p70 S6 kinase was not affected by EGCG
Abouantoun et al., Mol Cancer Ther 2009 (Medulloblastoma...) : Imatinib ( 1 µmol/L ) treatment of DAOY and D556 cells inhibited PDGF-BB- and serum mediated migration and invasion at 24 and 48 h, respectively, and concomitantly inhibited PDGF-BB activation of PDGFRB, Akt , and ERK but increased PTEN expression and activity
Lau et al., Clin Cancer Res 2009 (Liver Neoplasms...) : Akt/HIF-1alpha/PDGF-BB signaling regulated Akt to confer cisplatin resistance to HCC cell lines in vitro
Choi et al., Cardiovasc Res 2010 (MAP Kinase Signaling System) : Western blot analysis showed that PDGF-BB induced phosphorylation of Akt , p70S6K, and p38 was inhibited by piceatannol, but not resveratrol
Zheng et al., J Neurosci Res 2010 : PDGF-BB highly activated Akt , extracellular signal regulated kinase ( ERK ), c-jun amino-terminal kinase ( JNK ) and p38
Takami et al., Hepatology research : the official journal of the Japan Society of Hepatology 2010 : Western blot analysis showed that BB-PAC completely or partially inhibited PDGF-BB induced ERK and Akt phosphorylation, respectively
Lennartsson et al., Cell Signal 2010 : Under control conditions, PDGF-BB promoted a sustained Akt phosphorylation
Chan et al., Molecular vision 2010 : Furthermore, EGCG is shown to suppress PDGF-BB induced PDGF-beta receptors, downstream PI3K/Akt , and MAPK phosphorylation
Kim et al., Biol Pharm Bull 2010 (Cardiovascular Diseases) : In Western blot analysis, PDGF-BB stimulated ( 25 ng/ml ) phospholipase-C (PLC)gamma1 and Akt phosphorylation was inhibited by BST406 ( 0-10microM )
Nakamura et al., Int J Cardiol 2012 (Hypertension, Pulmonary) : PDGF-BB induced phosphorylation of Akt at 15 min, and Akt phosphorylation was inhibited by imatinib in IPAH-PASMCs ... Akt-I-1/2 ( 1 µmol/L ), an Akt inhibitor, in the presence of PDGF-BB significantly increased apoptotic cells compared with the control condition
Reyes-Gordillo et al., Am J Pathol 2011 (Liver Cirrhosis) : We found that PDGF-BB induced AKT binding to actin, and that Tß4 prevented this effect
Choi et al., Environ Toxicol Pharmacol 2011 : Additionally, AF inhibited PDGF-BB induced Akt and ERK1/2 phosphorylation
Hall-Glenn et al., PloS one 2012 : CCN2 induced PDGF-B expression in endothelial cells, and potentiated PDGF-B mediated Akt signaling in mural ( vascular smooth muscle/pericyte ) cells
Razmara et al., Cell communication and signaling : CCS 2013 : Consistently, triciribine, an inhibitor of the Akt pathway, suppressed PDGF-BB induced Akt phosphorylation without having any effect on S6 phosphorylation ... Furthermore, interfering with the PLC?/Ca2+/PKC pathway inhibited PDGF-BB induced Akt phosphorylation
Park et al., Exp Cell Res 2013 : Also, CPT decreased the expressions of G0/G1-specific regulatory proteins including cyclin dependent kinase (CDK)2, cyclin D1 and PCNA in PDGF-BB stimulated VSMCs. Pre-incubation of VSMCs with CPT significantly inhibited PDGF-BB induced Akt activation, whereas CPT did not affect PDGF-receptor beta phosphorylation, extracellular signal regulated kinase ( ERK ) 1/2 phosphorylation and phospholipase C (PLC)-?1 phosphorylation in PDGF-BB signaling pathway
Farrer et al., J Biol Chem 2013 (Neurofibromatosis 1) : The sustained Akt phosphorylation induced by PDGF-BB was inhibited by pretreatment of the cells with either the intracellular calcium chelator 1,2-bis ( 2-aminophenoxy ) ethane-N, N,N ', N'-tetraacetic acid tetrakis ( acetoxymethyl ) ester ( BAPTA-AM ) or the CaM antagonist W7, whereas the transient portion was not inhibited
Walker et al., Mol Pharmacol 1998 : Protein kinase B , a novel signaling protein kinase, was identified in BTSM cells and was activated by PDGF-BB and thrombin in a PtdIns 3-kinase dependent manner ; this may underlie mitogen stimulated activation of p70 ( s6k )