Gene interactions and pathways from curated databases and text-mining

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CASP5 — PDCD1

Text-mined interactions from Literome

Herceg et al., Mol Cell Biol 1999 (Necrosis) : The present study demonstrates that PARP cleavage prevents induction of necrosis during apoptosis and ensures appropriate execution of caspase mediated programmed cell death
Han et al., Neurobiol Dis 2000 (Brain Ischemia...) : During brain development, caspase-3 is required for normal levels of programmed cell death
Brown et al., J Biol Chem 2000 : However, a growing weight of evidence now suggests that not all forms of programmed cell death are caspase dependent
Deshmukh et al., J Cell Biol 2000 : Nerve growth factor (NGF) deprivation induces a Bax dependent, caspase dependent programmed cell death in sympathetic neurons
Achenbach et al., Antimicrob Agents Chemother 2000 : Preussin also induces programmed cell death ( apoptosis ), which requires caspase activation and involves the release of cytochrome c from mitochondria
Koo et al., Pharmacol Res 2002 : In previous studies, heat shock has been reported to induce the apoptosis or programmed cell death through the activation of caspase-3
Momoi et al., Neuroreport 2003 (Hyperplasia) : Strain-specific caspase-3 dependent programmed cell death in the early developing mouse forebrain
Bozhkov et al., Cell Death Differ 2004 : In this work, we have used synthetic peptide substrates containing caspase recognition sites and corresponding specific inhibitors to analyse the role of caspase-like activity in the regulation of programmed cell death during plant embryogenesis
Ekert et al., J Cell Biol 2004 : Therefore, Apaf-1, caspase-2, and caspase-9 are not required for programmed cell death of factor dependent cells, but merely affect its rate
Schmeck et al., Infect Immun 2004 : Moreover, programmed cell death could be strongly reduced by a caspase 6 inhibitor and a pan-caspase inhibitor
Schauser et al., Histochem Cell Biol 2005 (Disease Models, Animal...) : Salmonella typhimurium infection in the porcine intestine : evidence for caspase-3 dependent and -independent programmed cell death
Carmagnat et al., Oncogene 2006 (Lymphoma, Follicular...) : Dissociation of caspase mediated events and programmed cell death induced via HLA-DR in follicular lymphoma
Yang et al., J Biol Chem 2007 : The serine protease HtrA2/Omi is released from the mitochondria into the cytosol following apoptosis stimuli, leading to the programmed cell death in caspase dependent and -independent manners
Takemoto et al., Proc Natl Acad Sci U S A 2007 : In Drosophila, the salivary gland is sculpted by caspase mediated programmed cell death initiated by the steroid hormone 20-hydroxyecdysone ( ecdysone )
Lovekamp-Swan et al., Neuroscience 2007 (Disease Models, Animal...) : These results suggest that a high soy diet decreases both caspase dependent and caspase independent programmed cell death following tMCAO
Fink et al., Cell Microbiol 2007 (Salmonella Infections) : In contrast, macrophage infection triggers caspase-1 dependent proinflammatory programmed cell death , a recently recognized process termed pyroptosis, which is distinguished from other forms of cellular demise by its unique mechanism, features and inflammatory outcome
Nilakantan et al., American journal of physiology. Renal physiology 2008 (Reperfusion Injury) : These results demonstrate that 20-HETE overexpression can significantly exacerbate the cellular damage that is associated with renal IR injury and that the programmed cell death is mediated by activation of caspase-3 and is partially dependent on enhanced CYP4A generation of free radicals
Tarasov et al., PloS one 2008 (Aneuploidy...) : Ultimately, the loss of B-Myb and associated loss of Oct4 lead to an increase in early markers of differentiation prior to the activation of caspase mediated programmed cell death
Langberg et al., Br J Dermatol 2009 (Radiation Injuries) : Treatment with calcitriol inhibited both caspase dependent and -independent programmed cell death occurring within 48 h of irradiation and increased the colony formation capacity of irradiated cells
Huang et al., J Med Chem 2008 : The XIAP baculovirus IAP repeat 3 ( Bir3 ) domain binds directly to the N-terminal of caspase-9 , thus inhibiting programmed cell death
Zhang et al., Cancer Sci 2010 (Ovarian Neoplasms) : Mechanistically, PDCD4 significantly increased cisplatin induced cleavage of caspase-3 and caspase-8, but had only a slight impact on caspase-9 cleavage and the expression of Bax and Bcl-2 in vitro and in vivo
Chen et al., Infect Immun 2011 (Brucellosis) : The role of caspase-2 in regulating the programmed cell death of VTRS1 infected macrophages was confirmed in another study using caspase-2-knockout mice
Agarwal et al., J Biol Chem 2012 (Pharyngeal Diseases...) : The programmed cell death induced by SP-STP, which requires active transcription and de novo protein synthesis, is also caspase dependent
Chang et al., PloS one 2012 (Glioblastoma) : Furthermore, the caspase-3 , -8 and -9 inhibitor presented significant protection against E [ c ( RGDyK ) ] ( 2 ) peptide induced U87MG programmed cell death
Andries et al., J Control Release 2013 : The recognition of mRNA by the innate immune system was also associated with cell death, which proceeded in human respiratory cells via pyroptosis, a form of programmed cell death mediated by substantial overexpression of caspase-1
Song et al., Experimental neurobiology 2013 : Here, we report that 1 ) capsaicin induces caspase-3 dependent programmed cell death , which coincides with increased production of nitric oxide and peroxynitrite ; that 2 ) the prolonged capsaicin treatment induces a steady increase in the degree of capase-3 activation, which is prevented by the removal of capsaicin ; 3 ) and that blocking calcium entry and calcium mediated signaling prevents capsaicin induced cell death
Giordano et al., J Lipid Res 2013 : NLRP3 dependent caspase-1 activation in hypertrophic adipocytes likely induces obese adipocyte death by pyroptosis, a proinflammatory programmed cell death
Shaham et al., J Biol Chem 1998 : The Caenorhabditis elegans caspase CED-3 is essential for programmed cell death in this organism