◀ Back to NOTCH4
NOTCH4 — PCNA
Text-mined interactions from Literome
Sarmento et al., J Exp Med 2005
:
Cyclin dependent kinase inhibitors ( CKIs ) and
Notch receptor activation have been shown to influence adult stem cells and progenitors by altering stem cell self-renewal and proliferation
Carlson et al., Nature 2008
:
Importantly, endogenous Notch and pSmad3 antagonize each other in the control of satellite-cell proliferation, such that activation of
Notch blocks the TGF-beta dependent upregulation of the
cyclin dependent kinase (CDK) inhibitors p15, p16, p21 and p27, whereas inhibition of Notch induces them
Ma et al., Cell Prolif 2009
:
During injury recovery, disruption of Notch signalling by treatment with the gamma-secretase inhibitor reduced expression of ABCG2 and PCNA, but promoted expression of CK19, while persistent activation of
Notch signalling
promoted expression of ABCG2 and
PCNA , but reduced expression of CK19