Gene interactions and pathways from curated databases and text-mining

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EPO — PCNA

Text-mined interactions from Literome

Wang et al., Eur J Pharmacol 2008 : Moreover, recombinant human erythropoietin ( 10, 20 U/ml, 24 h ) promoted the expression of proliferating cell nuclear antigen in renal tubular cells stimulated by 10 mug/ml aristolochic acid ( 46.34 %, 48.11 % vs. 28.46 % )
Follo et al., Leukemia 2012 (Myelodysplastic Syndromes) : Here, we investigated the role of inositide pathways in low-risk MDS treated with EPO, mainly focusing on the Akt/PI-PLC ( Phosphoinositide-Phospholipase C ) gamma1 axis, which is activated by the EPO receptor, and PI-PLCbeta1/Cyclin D3 signaling, as Cyclin D3 is associated with hematopoietic proliferation and differentiation