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AKT1 — PCNA
Text-mined interactions from Literome
Basso et al., Oncogene 2002
(Breast Neoplasms) :
Downregulation of
D-cyclin was
due , in part, to loss of
Akt expression in response to drug ... Thus, in breast cancer cells with high HER2,
Akt activation by HER2/HER3 heterodimers is
required for
D-cyclin expression
Schönherr et al., Ann N Y Acad Sci 2002
:
Induction of dominan negative
Akt by a replication-deficient adenovirus
blocked p21 and
cyclin A synthesis, but had no effect on p27
Ostrakhovitch et al., Arch Biochem Biophys 2004
(Breast Neoplasms) :
Cyclin D1 expression and cell-cycle progression
followed the metal induced
Akt phosphorylation
Mirza et al., Mol Cell Biol 2004
(Pancreatic Neoplasms) :
Furthermore, we demonstrated that
AKT activation
led to sustained activation of
cyclin/cdk2 complexes that occurred concomitantly with the removal of RAF induced p21 ( Cip1 ) from cyclin E/cdk2 complexes
Fiala et al., Carcinogenesis 2005
(Lung Neoplasms...) :
The lesions were accompanied by increased expression of
proliferating cell nuclear antigen and
activation of the serine/threonine kinase
Akt in the bronchial epithelium
Xing et al., J Exp Med 2005
:
G5pr(-/-) B cells did not show abnormalities in the BCR mediated activation of Erks and NF-kappaB,
cyclin D2
induction , or
Akt activation
Spofford et al., J Biol Chem 2006
(Melanoma...) :
Cyclin D3 expression was enhanced in a cell panel of human melanoma cell lines compared with melanocytes and was
regulated by fibronectin mediated phosphatidylinositol
3-kinase/Akt signaling but not MEK activity
Radeff-Huang et al., J Biol Chem 2007
(Brain Neoplasms...) :
Furthermore,
cyclin D expression was increased by TNF-alpha in a SphK- and
Akt dependent manner ... We conclude that SphK dependent
Akt activation
plays a significant role in TNF-alpha induced
cyclin D expression and cell proliferation
Liu et al., Lab Invest 2009
(Disease Models, Animal...) :
PTK/ZK also induced cell cycle arrest, accompanied by increasing the expression of p27 ( Kip1 ) and downregulation of cyclin D1 and
cyclin E. PTK/ZK significantly
inhibited vascular endothelial growth factor ( VEGF ) expression, as well as VEGF simulated cell proliferation and phosphorylation of
Akt in activated HSCs
Zhu et al., Stroke 2009
(Intracranial Arteriovenous Malformations...) :
Immunostaining and Western blot revealed a more significant PTEN downregulation in PTEN methylated CCMs in comparison to PTEN unmethylated CCMs. Reduced PTEN expression was inversely correlated to the expression of
proliferating cell nuclear antigen and to the
activation of Erk1,2, but not of
Akt
Lee et al., Cell Mol Life Sci 2009
:
Galectin-1 induced increase in
cyclin expression and decrease in p27 ( kip1 ) was
blocked by
Akt inhibitor and rapamycin
Liu et al., BMC cancer 2010
(Brain Neoplasms...) :
Changes in several cell cycle regulators such as Cyclins D1 and E,
PCNA and Ki67, and several apoptosis related
regulators such as p53, p-JNK,
p-AKT , and PARP were determined by Western blot analysis
Park et al., Exp Cell Res 2013
:
In addition, inhibiting the PI3K/Akt pathway by LY294002 significantly enhanced the suppression of
PCNA expression and
Akt activation by CPT. These results suggest that the anti-proliferative activity of CPT is mediated in part by downregulating the PI3K/Akt signaling pathway