Gene interactions and pathways from curated databases and text-mining

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CASP7 — PCBD1

Text-mined interactions from Literome

Chiarle et al., J Immunol 1999 : CD30 mediated PCD requires caspase 1 and caspase 3, is not associated with the activation of NF-kappaB or c-Jun, but is totally prevented by Bcl-2
Poggi et al., Eur J Immunol 2000 (Leukemia, Myelomonocytic, Acute) : Interestingly, PCD elicited via LAIR-1 was not blocked by different caspase inhibitors, at variance with apoptosis induced via CD95/Fas, which was prevented by the caspase-1 and caspase-8 specific inhibitors
Elbaz et al., Cell Death Differ 2002 : The permeable peptide caspase inhibitors, zVAD-fmk and zBocD-fmk, blocked PCD induced by EIX or staurosporine
Momoi et al., Neuroreport 2003 (Hyperplasia) : Caspase-3-deficient 129/Sv mice show hyperplasia of the forebrain at embryonic day ( E ) 10.5, which suggests that caspase-3 dependent programmed cell death (PCD) plays an essential role in brain morphogenesis prior to neurogenesis ... However, little is known about region-specific caspase-3 dependent PCD in the developing forebrain ... We examined the caspase-3 dependent PCD in the ventral forebrain of 129/Sv and C57BL/6 mouse embryos ( E8.5-9 and E9.5 ) by double staining of TUNEL and antiserum against the active form of caspase-3 ( anti-m3D175 ) ... Thus, it is likely that this region is the site of the strain-specific caspase-3 dependent PCD
Rau et al., J Neurosci 2003 (Infarction, Middle Cerebral Artery) : The cerebral cortex exhibits caspase dependent programmed cell death (PCD) in many models of focal cerebral ischemia
Nussbaum et al., J Immunol 2004 : zVAD prevented caspase dependent PCD of freshly isolated virus-specific T cells in tissue culture, and a fluorescent analog, FITC-VAD, entered CD8 ( + ) T cells following in vivo injection ... We conclude that the contraction phase of the virus-specific T cell response is unlikely to require caspase dependent PCD
Jacobson et al., Trends Cell Biol 1997 : Although there has been considerable progress in elucidating the biochemical functions of caspases, how Bcl-2 related proteins regulate caspase activation and thereby PCD , has remained a mystery
Bidle et al., Eukaryotic cell 2008 : Here, we present morphological, biochemical, and molecular evidence of caspase mediated , autocatalytic programmed cell death (PCD) in the diatom Thalassiosira pseudonana in response to iron starvation
Oppenheim et al., J Neurosci 2008 : In contrast, caspase activity is not necessary for the normal PCD of more mature postmitotic neurons that are establishing synaptic connections
Pirger et al., Biol Cell 2009 : Our results provide evidence for a type of transmitter mediated pathway that regulates the PCD of secretory cells in a mitochondrial-caspase dependent manner
Mohseni et al., Autophagy 2009 : Mutants that are defective in the activation or execution of caspase dependent PCD fail to degrade and eliminate the AS but show no abatement in AS autophagy
Pan et al., Eur Biophys J 2009 : The emission peak at 526 nm disappeared and that of 476 nm increased after STS or bufalin treatment, but taxol treatment did not induce a significant change for the SCAT3 emission spectra, indicating that caspase-3 was activated during STS- or bufalin induced cell apoptosis, but was not involved in taxol induced PCD
Liu et al., Development 2009 : For the first time, we demonstrate that JH counteracts MET and GCE to prevent caspase dependent PCD in controlling fat body remodeling and larval-pupal metamorphosis in Drosophila
Bosch et al., Mol Plant 2008 : We also review data showing the involvement of the actin and microtubule cytoskeletons as well as that of a MAPK in signalling to caspase mediated PCD
Goldshmidt et al., PLoS Pathog 2010 : We propose that prolonged ER stress induces SLS, which serves as a unique death pathway, replacing the conventional caspase mediated PCD observed in higher eukaryotes
Hui et al., Cell Death Differ 2011 : Consistent with this, examination of both intrinsic and extrinsic forms of PCD in lines of murine embryonic fibroblasts demonstrate that loss of Smac/DIABLO alters both caspase dependent and caspase independent intrinsic PCD
Abdou et al., Insect Biochem Mol Biol 2011 : Precocious and enhanced caspase dependent programmed cell death (PCD) appears in fat body cells of Met ( 27 ) gce ( 2.5k ) during the early larval stages ... Consequently, expression of br occurs precociously in Met ( 27 ) gce ( 2.5k ), which may cause precocious caspase dependent PCD during the early larval stages ... Our data suggest a model in which Drosophila Met and Gce redundantly transduce JH action to prevent 20E induced caspase dependent PCD during larval molts by induction of Kr-h1 expression and inhibition of br expression
Sabirzhanov et al., J Neurochem 2012 (Neuroblastoma) : Furthermore, we demonstrated that HSP70 binds and potentially inactivates Apoptotic protease activating factor 1, as well as apoptosis inducing factor, key molecules involved in development of caspase dependent and caspase independent PCD , respectively ... Markers of caspase dependent PCD , including active caspase-3, caspase-9, and cleaved PARP were attenuated in neurons over expressing HSP70
Fogel et al., Journal of visualized experiments : JoVE 2012 : Other forms of PCD do not involve caspase activation and may be the end-result of prolonged autophagy
Peterson et al., J Neurosci 2012 (Aneuploidy) : The functional significance of neural mosaic aneuploidy is not known ; however, the generation of aneuploidy during embryonic neurogenesis, coincident with caspase dependent programmed cell death (PCD) , suggests that a cell 's karyotype could influence its survival within the CNS ... To address this hypothesis, PCD in the mouse embryonic cerebral cortex was attenuated by global pharmacological inhibition of caspases or genetic removal of caspase-3 or caspase-9
Li et al., Mol Cell Neurosci 1998 : Inhibition of caspase-3 by peptide inhibitors prevents the PCD of motoneurons following trophic factor deprivation in vitro, as well as in vivo