Tomescu et al., Lab Invest 2004
(Rhabdomyosarcoma, Embryonal) :
First, we demonstrated in both short-term and long-term systems that PAX3-FKHR upregulates expression of the gene encoding the chemokine receptor CXCR4 Tarnowski et al., Mol Cancer Res 2010
(Rhabdomyosarcoma) :
The upregulation of CXCR4 and downregulation of CXCR7 expression by PAX3-FKHR or hypoxia may give SDF-1 an advantage to better engage the CXCR4 receptor, thus increasing RMS motility