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AKT1 — PARP12

Text-mined interactions from Literome

Tapodi et al., J Biol Chem 2005 (Necrosis) : These data together with the finding that PARP inhibition in the absence of oxidative stress induced the phosphorylation and activation of Akt indicate that PARP inhibition induced Akt activation is dominantly responsible for the cytoprotection in oxidative stress
Szanto et al., Biochem Pharmacol 2009 : To understand the role of Akt activation in the combined use of cytostatic agent and PARP inhibition, we used taxol ( paclitaxel ) as an antineoplastic agent, which targets microtubules and up-regulates mitochondrial ROS production, together with ( i ) pharmacological inhibition ( PJ-34 ), ( ii ) siRNA knock-down and ( iii ) transdominant expression of the DNA binding domain of PARP-1
Gatson et al., Journal of neuroinflammation 2009 (Burns...) : In addition, we determined that in the estrogen treated rats there was an increase in the levels of phospho-ERK ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point, and that 17 beta-estradiol blocked the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of PARP ( p < 0.05 )
Mallon et al., Mol Cancer Ther 2010 : We are testing whether dual PI3K/mTOR inhibitors can durably suppress p-Akt , induce cleaved PARP , and cause tumor regression in a diverse set of human tumor xenograft models