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PARP1 — SIRT1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Rajamohan et al., Mol Cell Biol 2009
:
We also show that
SIRT1 negatively
regulates the activity of the
PARP1 gene promoter, thus suggesting that the deacetylase controls the PARP1 activity at the transcriptional level as well
Bai et al., Cell Metab 2011
:
PARP-1 inhibition
increases mitochondrial metabolism through
SIRT1 activation ... Also, the pharmacologic inhibition of
PARP in vitro and in vivo
increased NAD ( + ) content and
SIRT1 activity and enhanced oxidative metabolism
Massudi et al., PloS one 2012
:
Age associated increases in oxidative nuclear damage have been associated with
PARP mediated NAD ( + ) depletion and loss of
SIRT1 activity in rodents
Qin et al., Biochim Biophys Acta 2013
(Inflammation) :
PARP-1 inhibition
increased Sirt1 activity through an increased intracellular nicotinamide adenine dinucleotide ( NAD ( + ) ) level ...
PARP-1 inhibition
restored Sirt1 activity by increasing NAD ( + ) level and decreased iNOS and ICAM-1 expression by inhibiting NF-?B nuclear translocation and activity as well as NF-?B phosphorylation