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IGF1 — PARP1

Text-mined interactions from Literome

Spina Purrello et al., Mech Ageing Dev 2002 : In this investigation the effect of EGF, bFGF, IGF-I or INS on nuclear PARP and mitochondrial ADPRT activities were assessed in nuclei and mitochondria purified from developing ( 30 DIV ) or aging ( 90 and 190 DIV ) primary rat astrocyte cultures ... In this investigation the effect of EGF, bFGF, IGF-I or INS on nuclear PARP and mitochondrial ADPRT activities were assessed in nuclei and mitochondria purified from developing ( 30 DIV ) or aging ( 90 and 190 DIV ) primary rat astrocyte cultures ... In this investigation the effect of EGF, bFGF, IGF-I or INS on nuclear PARP and mitochondrial ADPRT activities were assessed in nuclei and mitochondria purified from developing ( 30 DIV ) or aging ( 90 and 190 DIV ) primary rat astrocyte cultures
Wadsworth et al., Endocrinology 2004 : Treatment with 150 microg/ml SPE for 24 h decreased IGF-I induced proliferation of P69 cells and induced cleavage of the enzyme poly ( ADP-ribose ) polymerase ( PARP ), an index of apoptosis
Beckert et al., Biochem Biophys Res Commun 2006 : Furthermore, the IGF-I mediated inhibition of PARP could be demonstrated as a result of protein phosphorylation since phosphorylation of PARP decreased its activity in vitro and IGF-I treatment of endothelial cells induced PARP phosphorylation ... The IGF-I mediated phosphorylation and inhibition of PARP represent a novel mechanism of VEGF protein expression
Moore et al., Blood 2013 (Thrombocythemia, Essential) : Indeed, we found that platelets from JAK2V617F positive ET patients have significantly reduced phosphorylation of the PI3 kinase substrate Akt, and have reduced activation of Rap1 in response to thrombopoietin, IGF-1 , ADP, SFLLRN, and thrombin