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CASP7 — PAK2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Chan et al., J Cell Biochem 2000
(Carcinoma, Squamous Cell) :
We report that genistein, an isoflavone compound with known inhibitory activities to protein tyrosine kinases ( PTKs ) and topoisomerase-II ( topo-II ), can prevent UV irradiation induced apoptotic biochemical changes ( DNA fragmentation,
caspase-3 activation , and cleavage/activation of
PAK2 ) in A431 cells
Chan et al., J Cell Biochem 2003
(Carcinoma, Squamous Cell) :
In this study we demonstrate that curcumin ( Cur ), the yellow pigment of Curcuma longa with known anti-oxidant and anti-inflammatory properties, can prevent UV irradiation induced apoptotic changes, including c-Jun N-terminal kinase (JNK) activation, loss of mitochondrial membrane potential ( MMP ), mitochondrial release of cytochrome C,
caspase-3 activation , and cleavage/activation of
PAK2 in A431 cells
Jakobi et al., Drug Resist Updat 2004
(Neoplasms) :
Caspase activated MEKK1 translocates from a particulate compartment to the cytosol ;
caspase activated Mst-1 and
PAK-2 translocate from the cytoplasm to the nucleus
Chan et al., J Cell Biochem 2004
(Carcinoma) :
Previously, we showed that PDT stimulates
caspase-3 activation and subsequent cleavage and
activation of
p21 activated kinase 2 (PAK2) in human epidermal carcinoma A431 cells ... We report that curcumin prevented PDT induced JNK activation, mitochondrial release of cytochrome c,
caspase-3 activation , and cleavage of
PAK2
Koeppel et al., J Biol Chem 2004
:
Identification and characterization of PS-GAP as a novel regulator of
caspase activated
PAK-2 ... Activation of full-length PAK-2 by Rac or Cdc42 stimulates cell survival and protects cells from cell death, whereas
caspase activated
PAK-2p34 induces a cell death response ... Although many proteins have been shown to interact with and regulate full-length PAK-2, little is known about the regulation of
caspase activated
PAK-2p34 ... Here, we identify PS-GAP as a regulator of
caspase activated
PAK-2p34 ... PS-GAP interacts specifically with
caspase activated
PAK-2p34 , but not active or inactive full-length PAK-2, through a region between the GAP and SH3 domains
Vilas et al., Proc Natl Acad Sci U S A 2006
:
Posttranslational myristoylation of
caspase activated
p21 activated protein kinase 2 (PAK2) potentiates late apoptotic events
Chan et al., Food Chem Toxicol 2006
(Necrosis) :
Here, we demonstrate that curcumin can induce apoptotic changes, including JNK activation,
caspase-3 activation , and cleavage of PARP and
PAK2 , at treatment concentrations lower than 25 microM in human osteoblast cells
Huang et al., Environ Toxicol 2009
:
Early-stage JNK activation is solely ROS dependent, whereas late-stage activation is dependent on ROS mediated caspase activity, and regulated by
caspase induced activation of
PAK2
Hsuuw et al., Ann N Y Acad Sci 2009
:
Experiments using caspase-3 inhibitors and antisense oligonucleotides against PAK2 showed that
caspase-3 activation is
required for
PAK2 activation and both of these activations are required for GKB induced apoptosis in ESC-B5 cells
Marlin et al., Mamm Genome 2011
:
Functional PAK-2 knockout and replacement with a caspase cleavage-deficient mutant in mice reveals differential requirements of full-length PAK-2 and
caspase activated
PAK-2p34 ... Activation of full-length PAK-2 by the monomeric GTPases Cdc42 or Rac stimulates cell survival, whereas
caspase activation of
PAK-2 to the PAK-2p34 fragment is involved in the apoptotic response ... In this study we use functional knockout of PAK-2 and gene replacement with the caspase cleavage-deficient PAK-2D212N mutant to differentiate the biological functions of full-length PAK-2 and
caspase activated
PAK-2p34 ... However, deficiency of
caspase activation of
PAK-2 decreased spontaneous cell death of primary mouse embryonic fibroblasts and increased cell growth at high cell density ... In contrast, stress induced cell death by treatment with the anti-cancer drug cisplatin was not reduced by deficiency of
caspase activation of
PAK-2 , but switched from an apoptotic to a nonapoptotic, caspase independent mechanism ... Homozygous PAK-2D212N primary mouse embryonic fibroblasts that lack the ability to generate the proapoptotic PAK-2p34 show less activation of the effector caspase 3, 6, and 7, indicating that
caspase activation of
PAK-2 amplifies the apoptotic response through a positive feedback loop resulting in more activation of effector caspases
Rudel et al., Science 1997
:
Membrane and morphological changes in apoptotic cells regulated by
caspase mediated activation of
PAK2 ... Apoptosis of Jurkat T cells induced the
caspase mediated proteolytic cleavage of
p21 activated kinase 2 (PAK2)