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AKT1 — PAK2
Text-mined interactions from Literome
Tang et al., J Biol Chem 2000
:
We found that activated Akt stimulated Pak, whereas a dominant negative
Akt inhibited Ras activation of
Pak in transfection assays ... Akt stimulation of Pak was not inhibited by dominant negative mutants of either Rac or Cdc42 suggesting that
Akt activated
Pak through a GTPase independent mechanism
Zhou et al., J Biol Chem 2006
:
Opposing
roles for
Akt1 and Akt2 in
Rac/Pak signaling and cell migration
Somanath et al., Oncogene 2009
(Cell Transformation, Neoplastic...) :
Importantly, disruption of the function of
PAK not only uncoupled the activation of Akt from that of extracellular signal regulated kinases, but also greatly
reduced the capacity of
Akt to act as a transforming oncogene
Chow et al., PloS one 2010
(Cell Transformation, Neoplastic...) :
However, in tumors, loss of
Pak activity does not
reduce Erk or
Akt activity, two signaling proteins that are thought to mediate Pak function in growth factor pathways
Ju et al., Cell Signal 2013
:
Finally,
PAK1/2 is also recruited to the rafts by the S4-PKCa complex and is
required for
AKT activation
Sato et al., J Gastroenterol Hepatol 2013
:
Western blotting analyses showed that TGF-ß stimulated Akt and PAK2 in all three hepatoma cell lines, and phosphorylated
PAK2 was
blocked by
Akt inhibitor