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FLNA — PAK1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: PAK1 — FLNA (in vitro) Vadlamudi et al., Nat Cell Biol 2002*
• IRef Hprd Interaction: PAK1 — FLNA (in vivo) Vadlamudi et al., Nat Cell Biol 2002*
• IRef Hprd Interaction: PAK1 — FLNA (two hybrid) Vadlamudi et al., Nat Cell Biol 2002*

Text-mined interactions from Literome

Vadlamudi et al., Nat Cell Biol 2002 : The FLNa binding site in Pak1 is localized between amino acids 52 and 132 in the conserved Cdc42/Rac interacting ( CRIB ) domain ; accordingly, FLNa binding to the CRIB domain stimulates Pak1 kinase activity ... Our results indicate that FLNa may be essential for Pak1 induced cytoskeletal reorganization and that the two-way regulatory interaction between Pak1 and FLNa may contribute to the local stimulation of Pak1 activity and its targets in cytoskeletal structures
Maceyka et al., Mol Cell Biol 2008 : SphK1 was required for heregulin induced migration, lamellipodia formation, activation of PAK1 , and subsequent FLNa phosphorylation