◀ Back to AKT1
AKT1 — PAK1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Tang et al., J Biol Chem 2000
:
We found that activated Akt stimulated Pak, whereas a dominant negative
Akt inhibited Ras activation of
Pak in transfection assays ... Akt stimulation of Pak was not inhibited by dominant negative mutants of either Rac or Cdc42 suggesting that
Akt activated
Pak through a GTPase independent mechanism
Kettritz et al., J Am Soc Nephrol 2002
:
TNF-alpha stimulation
increased association of
PAK1 with
Akt
Zhou et al., Mol Cell Biol 2003
:
We found that
Akt phosphorylated and modestly
activated Pak1 in vitro
Menard et al., FEBS Lett 2004
:
Wortmannin, which inhibits phosphoinositide 3-kinase ( PI3-kinase ) activity, and expression of a dominant/negative form of
Akt were
sufficient to abrogate the activation of
PAK1 that was induced by Gbetagamma
Yuan et al., J Biol Chem 2005
:
Nonphosphorylatable ArgBP2gamma-4A and SH3 domain truncated mutant ArgBP2gamma inhibit
Akt induced
PAK1 activation and reduce Akt and PAK1 phosphorylation of Bad and antiapoptotic function
Zhou et al., J Biol Chem 2006
:
Opposing
roles for
Akt1 and Akt2 in
Rac/Pak signaling and cell migration ... Both Akt2 and
Akt1 associated in complexes with Pak1, but only Akt2
inhibited Pak1 in kinase assays, suggesting an underlying molecular basis for the different cellular phenotypes
Mao et al., J Mol Cell Cardiol 2008
(Hypertrophy) :
Pak1 overexpression
induces Akt phosphorylation at both Ser473 and Thr308 in cardiomyocytes
Somanath et al., Oncogene 2009
(Cell Transformation, Neoplastic...) :
The
role of
PAK-1 in activation of MAP kinase cascade and oncogenic transformation by
Akt ... Importantly, disruption of the function of
PAK not only uncoupled the activation of Akt from that of extracellular signal regulated kinases, but also greatly
reduced the capacity of
Akt to act as a transforming oncogene
Chow et al., PloS one 2010
(Cell Transformation, Neoplastic...) :
However, in tumors, loss of
Pak activity does not
reduce Erk or
Akt activity, two signaling proteins that are thought to mediate Pak function in growth factor pathways
Ju et al., Cell Signal 2013
:
Finally,
PAK1/2 is also recruited to the rafts by the S4-PKCa complex and is
required for
AKT activation
Yang et al., Journal of biomedical research 2011
:
Activation of
Rac1-PI3K/Akt is
required for epidermal growth factor induced
PAK1 activation and cell migration in MDA-MB-231 breast cancer cells