Gene interactions and pathways from curated databases and text-mining

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MAPK6 — NTRK1

Text-mined interactions from Literome

Zhu et al., Mol Carcinog 2002 (Disease Progression...) : NGF has the potential to stimulate the growth of some pancreatic cancer cell lines, and this effect is mediated by the phosphorylation of tyrosine kinase receptor A and mitogen activated protein kinase activation ; it is dependent on the expression levels of tyrosine kinase receptor A and p75 receptors
Parran et al., Toxicological sciences : an official journal of the Society of Toxicology 2005 (Neuroblastoma) : In controls, the activation of TrkA MAPK and PKC-delta peaked after 5 min of exposure to NGF and then decreased but was still detectable at 60 min. Concurrent exposure to increasing concentrations of thimerosal and NGF for 5 min resulted in a concentration dependent decrease in TrkA and MAPK phosphorylation, which was evident at 50 nM for TrkA and 100 nM for MAPK
Appert-Collin et al., Int J Immunopathol Pharmacol 2005 : These findings suggest that this compound does not involve MAPK activation by TrkA receptor stimulation but acts by MAP kinase pathway by a pertussis toxin-sensitive mechanism involving 5-HT1A receptors, p21 Ras and MEK-1 and by PKC and Akt pathways
Cushing et al., J Neurosci Res 2005 (Neuroblastoma) : Immunoblot analysis demonstrated that Cx43 and the mitogen activated protein kinase ( MAPK ), ERK-1/2, were phosphorylated in response to TrkA activation via NGF and that phosphorylation could be prevented by treatment with the MEK-1/2 inhibitor U0126
Moughal et al., J Neurochem 2006 : In contrast, the stimulation of PC12 cells with LPA leads to a predominant G ( i ) alpha2 mediated Trk A-independent activation of p42/p44 MAPK , where Gbetagamma subunits play a diminished role
Akpan et al., Brain Res 2008 (Chagas Disease) : It also requires TrkA dependent PI3K and MAPK/Erk signaling pathways because PDNF stimulation of cholinergic transcripts is abolished by specific pharmacological inhibitors
Schmitz et al., Cell Mol Neurobiol 2011 : Our data showed that cavtratin suppresses the NGF induced phosphorylation of TrkA as well as the activation of MAPK in porcine oligodendrocytes significantly
Alsina et al., PloS one 2012 (MAP Kinase Signaling System) : At molecular level, our findings indicate that ectopic expression of a mutated form of Spry4 ( Y53A ), in which a conserved tyrosine residue was replaced, fail to block both TrkA mediated Erk/MAPK activation and neurite outgrowth induced by NGF, suggesting that an intact tyrosine 53 site is required for the inhibitory effect of Spry4 on NGF signaling
Chaves et al., Zygote 2013 : The TrkA receptor activates predominantly phosphatidylinositol-3-kinase (PI3K) and mitogenic activated protein kinase ( MAPK ) to promote cell survival and proliferation
Cattaneo et al., International journal of molecular sciences 2013 : Upon activation, intracellular domains of FPR2 mediate signaling to G-proteins, which trigger several agonist dependent signal transduction pathways, including activation of phospholipase C (PLC), protein kinase C ( PKC ) isoforms, the phosphoinositide 3-kinase (PI3K)/protein kinase B ( Akt ) pathway, the mitogen activated protein kinase ( MAPK ) pathway, p38MAPK, as well as the phosphorylation of cytosolic tyrosine kinases, tyrosine kinase receptor transactivation , phosphorylation and nuclear translocation of regulatory transcriptional factors, release of calcium and production of oxidants
Tam et al., Blood 1997 : NGF stimulation of HMC-1 cells induced tyrosine phosphorylation of TrkA protein, increased expression of the early response genes c-fos and NGF1-A, and activation of ERK-mitogen activated protein ( MAP ) kinase , results which indicate that TrkA receptors in HMC-1 cells are fully functional