Gene interactions and pathways from curated databases and text-mining

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AKT1 — NRG2

Text-mined interactions from Literome

Goldshmit et al., J Biol Chem 2001 : Furthermore, the downstream effector of PI3K, protein kinase B/AKT, is activated by NRG in the presence of H ( 2 ) O ( 2 ), and protein kinase B/AKT activation is inhibited by LY294002 ... Furthermore, the downstream effector of PI3K, protein kinase B/AKT, is activated by NRG in the presence of H ( 2 ) O ( 2 ), and protein kinase B/AKT activation is inhibited by LY294002
Lemmens et al., Circulation 2004 : In cultured rat cardiomyocytes, NRG-1beta enhanced nitrite production and resulted in phosphorylation of endothelial NO synthase and the serine/threonine kinase Akt
Hellyer et al., Am J Physiol Cell Physiol 2006 : NRG also increased phosphorylation of Akt , a downstream effector of PI3K ... This NRG induced increase in Akt phosphorylation and protein synthesis was completely blocked by wortmannin, an inhibitor of PI3K but was unaffected by PD-98059, an inhibitor of MEK
Di Segni et al., J Mol Neurosci 2006 : NRG induces prolonged activation of PKB/Akt and Erk ... NRG induces prolonged activation of PKB/Akt and Erk ... Taken together, these results indicate that in PC12-ErbB4 cells, the NRG induced neuroprotective effect from MPP+ treatment, requires PI3K/PKB/Akt and Ras/MapK signaling networks ... Taken together, these results indicate that in PC12-ErbB4 cells, the NRG induced neuroprotective effect from MPP+ treatment, requires PI3K/PKB/Akt and Ras/MapK signaling networks
Kéri et al., Neurochem Int 2009 : In conclusion, NRG1 induced AKT phosphorylation is decreased in schizophrenia but not in other psychotic disorders
Kéri et al., Schizophr Bull 2011 : There were 3 significant predictors of delusional ideas : decreased habituation, NRG1 induced AKT phosphorylation, and anxiety ... These results suggest that decreased habituation of arousal, NRG1 induced AKT phosphorylation, and anxiety are related to delusional ideation in the general population
Schmukler et al., PloS one 2012 (MAP Kinase Signaling System...) : We also demonstrated that NRG- induced autophagy is independent of mammalian target of rapamycin (mTOR) inhibition since NRG induces Akt and S6K activation
Bernard et al., J Biol Chem 2012 (Disease Models, Animal...) : Furthermore, in contrast to related ligands, NRG4 enhanced cell survival but not proliferation or migration, and stimulated phosphorylation of the anti-apoptotic mediator Akt but not ERK MAPK