Gene interactions and pathways from curated databases and text-mining

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AKT1 — NRG1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Sweeney et al., J Biol Chem 2001 : Although the growth factors epidermal growth factor (EGF) and neuregulin (NRG) 1 similarly stimulated Erk1/2 in MDA-MB-361 cells, EGF acting through an EGF receptor/ErbB2 heterodimer preferentially stimulated protein kinase C, and NRG1beta acting through an ErbB2/ErbB3 heterodimer preferentially stimulated Akt
Goldshmit et al., J Biol Chem 2001 : Furthermore, the downstream effector of PI3K, protein kinase B/AKT, is activated by NRG in the presence of H ( 2 ) O ( 2 ), and protein kinase B/AKT activation is inhibited by LY294002 ... Furthermore, the downstream effector of PI3K, protein kinase B/AKT, is activated by NRG in the presence of H ( 2 ) O ( 2 ), and protein kinase B/AKT activation is inhibited by LY294002
Lemmens et al., Circulation 2004 : In cultured rat cardiomyocytes, NRG-1beta enhanced nitrite production and resulted in phosphorylation of endothelial NO synthase and the serine/threonine kinase Akt
Chae et al., J Neurophysiol 2005 : NRG1- and TGF(beta)1 evoked stimulation of K ( Ca ) is blocked by inhibitors of PI3K by overexpression of a dominant negative form of Akt , by overexpression of CTMP, an endogenous negative regulator of Akt, and by application of the Akt inhibitor 1L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate ( HIMO )
Hellyer et al., Am J Physiol Cell Physiol 2006 : NRG also increased phosphorylation of Akt , a downstream effector of PI3K ... This NRG induced increase in Akt phosphorylation and protein synthesis was completely blocked by wortmannin, an inhibitor of PI3K but was unaffected by PD-98059, an inhibitor of MEK
Di Segni et al., J Mol Neurosci 2006 : NRG induces prolonged activation of PKB/Akt and Erk ... NRG induces prolonged activation of PKB/Akt and Erk ... Taken together, these results indicate that in PC12-ErbB4 cells, the NRG induced neuroprotective effect from MPP+ treatment, requires PI3K/PKB/Akt and Ras/MapK signaling networks ... Taken together, these results indicate that in PC12-ErbB4 cells, the NRG induced neuroprotective effect from MPP+ treatment, requires PI3K/PKB/Akt and Ras/MapK signaling networks
Kéri et al., Neurochem Int 2009 : In conclusion, NRG1 induced AKT phosphorylation is decreased in schizophrenia but not in other psychotic disorders ... In conclusion, NRG1 induced AKT phosphorylation is decreased in schizophrenia but not in other psychotic disorders
Kéri et al., Schizophr Bull 2011 : The aim of this study was to investigate the relationship among neuregulin 1 (NRG1) stimulated AKT phosphorylation ( a putative marker of psychosis ), orienting response habituation, delusional ideas, anxiety, and depression in nonclinical individuals ... There were 3 significant predictors of delusional ideas : decreased habituation, NRG1 induced AKT phosphorylation, and anxiety ... These results suggest that decreased habituation of arousal, NRG1 induced AKT phosphorylation, and anxiety are related to delusional ideation in the general population ... These results suggest that decreased habituation of arousal, NRG1 induced AKT phosphorylation, and anxiety are related to delusional ideation in the general population
Seres et al., Neurochem Int 2010 (Genetic Predisposition to Disease) : Patients with schizophrenia exhibit decreased neuregulin 1 (NRG1) stimulated AKT phosphorylation in peripheral lymphoblasts
Sei et al., PloS one 2010 : NRG1 induced AKT1 phosphorylation was significantly diminished in Val carriers compared to Met carriers in both normal subjects and in patients ... NRG1 induced translocation of AKT1 to the plasma membrane also was impaired in Val carriers, while PIP ( 3 ) levels were not decreased ... Transfection of SH-SY5Y cells with a COMT Val construct increased COMT activity and significantly decreased PS levels as well as NRG1 induced AKT1 phosphorylation and migration
Calvo et al., Glia 2011 (MAP Kinase Signaling System...) : We found that neuregulin-1 in vitro induced phosphorylation of ERK1/2 and Akt without activating p38MAPK
Szamosi et al., J Psychiatr Res 2012 (Genetic Predisposition to Disease) : Evidence suggests that neuregulin 1 (NRG1) induces decreased AKT phosphorylation in schizophrenia relative to healthy controls, which may be related to dysfunctional neurodevelopment and neuroplasticity
Schmukler et al., PloS one 2012 (MAP Kinase Signaling System...) : We also demonstrated that NRG- induced autophagy is independent of mammalian target of rapamycin (mTOR) inhibition since NRG induces Akt and S6K activation
Bernard et al., J Biol Chem 2012 (Disease Models, Animal...) : Furthermore, in contrast to related ligands, NRG4 enhanced cell survival but not proliferation or migration, and stimulated phosphorylation of the anti-apoptotic mediator Akt but not ERK MAPK