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AKT1 — NRG1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Sweeney et al., J Biol Chem 2001
:
Although the growth factors epidermal growth factor (EGF) and neuregulin (NRG) 1 similarly stimulated Erk1/2 in MDA-MB-361 cells, EGF acting through an EGF receptor/ErbB2 heterodimer preferentially stimulated protein kinase C, and
NRG1beta acting through an ErbB2/ErbB3 heterodimer preferentially
stimulated Akt
Goldshmit et al., J Biol Chem 2001
:
Furthermore, the downstream effector of PI3K, protein kinase B/AKT, is activated by
NRG in the presence of H ( 2 ) O ( 2 ), and
protein kinase B/AKT activation is
inhibited by LY294002 ... Furthermore, the downstream effector of PI3K, protein kinase B/AKT, is activated by
NRG in the presence of H ( 2 ) O ( 2 ), and protein kinase
B/AKT activation is
inhibited by LY294002
Lemmens et al., Circulation 2004
:
In cultured rat cardiomyocytes,
NRG-1beta enhanced nitrite production and
resulted in phosphorylation of endothelial NO synthase and the serine/threonine kinase
Akt
Chae et al., J Neurophysiol 2005
:
NRG1- and TGF(beta)1 evoked stimulation of K ( Ca ) is
blocked by inhibitors of PI3K by overexpression of a dominant negative form of
Akt , by overexpression of CTMP, an endogenous negative regulator of Akt, and by application of the Akt inhibitor 1L-6-hydroxymethyl-chiro-inositol 2- ( R ) -2-O-methyl-3-O-octadecylcarbonate ( HIMO )
Hellyer et al., Am J Physiol Cell Physiol 2006
:
NRG also
increased phosphorylation of
Akt , a downstream effector of PI3K ... This
NRG induced increase in
Akt phosphorylation and protein synthesis was completely blocked by wortmannin, an inhibitor of PI3K but was unaffected by PD-98059, an inhibitor of MEK
Di Segni et al., J Mol Neurosci 2006
:
NRG induces prolonged activation of
PKB/Akt and Erk ...
NRG induces prolonged activation of
PKB/Akt and Erk ... Taken together, these results indicate that in PC12-ErbB4 cells, the
NRG induced neuroprotective effect from MPP+ treatment, requires
PI3K/PKB/Akt and Ras/MapK signaling networks ... Taken together, these results indicate that in PC12-ErbB4 cells, the
NRG induced neuroprotective effect from MPP+ treatment, requires
PI3K/PKB/Akt and Ras/MapK signaling networks
Kéri et al., Neurochem Int 2009
:
In conclusion,
NRG1 induced
AKT phosphorylation is decreased in schizophrenia but not in other psychotic disorders ... In conclusion,
NRG1 induced
AKT phosphorylation is decreased in schizophrenia but not in other psychotic disorders
Kéri et al., Schizophr Bull 2011
:
The aim of this study was to investigate the relationship among
neuregulin 1 (NRG1) stimulated
AKT phosphorylation ( a putative marker of psychosis ), orienting response habituation, delusional ideas, anxiety, and depression in nonclinical individuals ... There were 3 significant predictors of delusional ideas : decreased habituation,
NRG1 induced
AKT phosphorylation, and anxiety ... These results suggest that decreased habituation of arousal,
NRG1 induced
AKT phosphorylation, and anxiety are related to delusional ideation in the general population ... These results suggest that decreased habituation of arousal,
NRG1 induced
AKT phosphorylation, and anxiety are related to delusional ideation in the general population
Seres et al., Neurochem Int 2010
(Genetic Predisposition to Disease) :
Patients with schizophrenia exhibit decreased
neuregulin 1 (NRG1) stimulated
AKT phosphorylation in peripheral lymphoblasts
Sei et al., PloS one 2010
:
NRG1 induced
AKT1 phosphorylation was significantly diminished in Val carriers compared to Met carriers in both normal subjects and in patients ...
NRG1 induced translocation of
AKT1 to the plasma membrane also was impaired in Val carriers, while PIP ( 3 ) levels were not decreased ... Transfection of SH-SY5Y cells with a COMT Val construct increased COMT activity and significantly decreased PS levels as well as
NRG1 induced
AKT1 phosphorylation and migration
Calvo et al., Glia 2011
(MAP Kinase Signaling System...) :
We found that
neuregulin-1 in vitro
induced phosphorylation of ERK1/2 and
Akt without activating p38MAPK
Szamosi et al., J Psychiatr Res 2012
(Genetic Predisposition to Disease) :
Evidence suggests that
neuregulin 1 (NRG1) induces decreased
AKT phosphorylation in schizophrenia relative to healthy controls, which may be related to dysfunctional neurodevelopment and neuroplasticity
Schmukler et al., PloS one 2012
(MAP Kinase Signaling System...) :
We also demonstrated that NRG- induced autophagy is independent of mammalian target of rapamycin (mTOR) inhibition since
NRG induces
Akt and S6K activation
Bernard et al., J Biol Chem 2012
(Disease Models, Animal...) :
Furthermore, in contrast to related ligands,
NRG4 enhanced cell survival but not proliferation or migration, and
stimulated phosphorylation of the anti-apoptotic mediator
Akt but not ERK MAPK