Gene interactions and pathways from curated databases and text-mining

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AKT1 — NR4A1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Masuyama et al., J Biol Chem 2001 : Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis ... We found that Akt inhibited the DNA binding activity of Nur77 and stimulated its association with 14-3-3 in a phosphorylation site dependent manner
Rakatzi et al., Diabetes 2003 (MAP Kinase Signaling System) : Predominant activation of IRS-2 was also observed in adult cardiomyocytes where HMR 1964 increased 3-O-methylglucose transport and the activation of Akt and glycogen synthase kinase-3 to the same extent as human insulin
Han et al., Oncogene 2006 : Together, our results demonstrate that both activation of JNK and inhibition of Akt play a role in translocation of Nur77 from the nucleus to the cytoplasm
Hiromura et al., J Biol Chem 2006 : We hypothesized that TCL1 transactivity is regulated through Akt induced phosphorylation of Nur77/NGFI-B in vivo
Liu et al., J Endocrinol 2008 : Taken together, these observations suggest that GLP-1 inhibits TNF-alpha mediated PAI-1 induction in vascular endothelial cells, and this effect may involve Akt mediated signalling events and the modulation of Nur77 expression and NP binding to the PAI-1 NBRE