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AKT1 — NR4A1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Masuyama et al., J Biol Chem 2001
:
Akt inhibits the orphan nuclear receptor
Nur77 and T-cell apoptosis ... We found that
Akt inhibited the DNA binding activity of
Nur77 and stimulated its association with 14-3-3 in a phosphorylation site dependent manner
Rakatzi et al., Diabetes 2003
(MAP Kinase Signaling System) :
Predominant activation of IRS-2 was also observed in adult cardiomyocytes where
HMR 1964
increased 3-O-methylglucose transport and the activation of
Akt and glycogen synthase kinase-3 to the same extent as human insulin
Han et al., Oncogene 2006
:
Together, our results demonstrate that both activation of JNK and inhibition of
Akt play a role in translocation of
Nur77 from the nucleus to the cytoplasm
Hiromura et al., J Biol Chem 2006
:
We hypothesized that TCL1 transactivity is regulated through
Akt induced phosphorylation of
Nur77/NGFI-B in vivo
Liu et al., J Endocrinol 2008
:
Taken together, these observations suggest that GLP-1 inhibits TNF-alpha mediated PAI-1 induction in vascular endothelial cells, and this effect may involve
Akt mediated signalling events and the modulation of
Nur77 expression and NP binding to the PAI-1 NBRE