Gene interactions and pathways from curated databases and text-mining

◀ Back to CASP5

CASP5 — NR0B1

Text-mined interactions from Literome

Kwon et al., Life Sci 2007 : We investigated dextran sulfate sodium (DSS) induced IL-1 beta production and caspase-1 activities in murine peritoneal macrophages ( pM phi ) ... IL-1 beta release and caspase-1 activity induced by DSS were significantly inhibited by a MAPK kinase 1/2 inhibitor, a p38 MAPK inhibitor, and NAC, however, not by JNK1/2 or a protein kinase C inhibitor
Bauer et al., Gut 2010 (Colitis...) : IL-1beta secretion was abrogated in macrophages lacking NLRP3, ASC or caspase-1, indicating that DSS activates caspase-1 via the NLRP3 inflammasome