Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Liu et al., J Leukoc Biol 2001 (Gout) : PP1 inhibited crystal induced phosphorylation of ERK1/2 and IkappaBalpha and suppressed IkappaB kinase (IKK) activation and NF-kappaB binding to the IL-8 promoter, signals that mediate MSU induced IL-8 expression
Mitsuhashi et al., Int J Oncol 2008 : These results suggest that the PP1 positively regulates the TNFalpha induced NF-kappaB pathway at the level of IKK activation